Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

The Association of Vitamin D Supplementation With the Outcome in Critically Ill Children

Phase 4
Completed
Conditions
Interventions
First Posted Date
2020-09-03
Last Posted Date
2020-09-03
Lead Sponsor
Dr Mustahsin Khalil
Target Recruit Count
96
Registration Number
NCT04536831
Locations
🇵🇰

King Edward Medical University Lahore, Lahore, Punjab, Pakistan

Efficacy of Vitamin D Supplementation to Prevent the Risk of Acquiring COVID-19 in Healthcare Workers

Phase 3
Completed
Conditions
Interventions
First Posted Date
2020-09-02
Last Posted Date
2021-12-22
Lead Sponsor
Coordinación de Investigación en Salud, Mexico
Target Recruit Count
321
Registration Number
NCT04535791
Locations
🇲🇽

Hospital Centro Medico Nacional Siglo XXI, Mexico City, Distrito Federal, Mexico

Efficacy of Vitamin D Treatment in Pediatric Patients Hospitalized by COVID-19

Phase 3
Completed
Conditions
Interventions
First Posted Date
2020-08-06
Last Posted Date
2022-04-08
Lead Sponsor
Coordinación de Investigación en Salud, Mexico
Target Recruit Count
45
Registration Number
NCT04502667
Locations
🇲🇽

Hospital Centro Medico Nacional Siglo XXI, Mexico City, Distrito Federal, Mexico

Vitamin D and Methotrexate Adverse Effects

First Posted Date
2020-07-27
Last Posted Date
2020-07-27
Lead Sponsor
Assiut University
Target Recruit Count
50
Registration Number
NCT04488237

The Efficacy and the Safety of Vitamin D3 30,000 IU for Loading Dose Schedules

Phase 3
Completed
Conditions
Interventions
First Posted Date
2020-07-20
Last Posted Date
2022-03-04
Lead Sponsor
Semmelweis University
Target Recruit Count
75
Registration Number
NCT04476511
Locations
🇭🇺

Szalay János Outpatient Clinic, Hajdúnánás, Hungary

🇭🇺

Semmelweis University - Dept. of Medicine and Oncology, Budapest, Hungary

🇭🇺

Uno Medical Trials Kft., Budapest, Hungary

and more 4 locations

Vitamin D in Egyptian Children With Atopic Dermatitis

Phase 3
Completed
Conditions
Interventions
First Posted Date
2020-07-13
Last Posted Date
2020-07-14
Lead Sponsor
National Hepatology & Tropical Medicine Research Institute
Target Recruit Count
92
Registration Number
NCT04468711
Locations
🇪🇬

NHTRMI, Cairo, Egypt

Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-06-23
Last Posted Date
2020-06-23
Lead Sponsor
Dubai Health Authority
Target Recruit Count
45
Registration Number
NCT04443387

Determining the Effect of Vitamin D, Dyslipidemia and Microvascular in Patients With Type 2 Diabetes

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-06-19
Last Posted Date
2020-06-19
Lead Sponsor
Baqiyatallah Medical Sciences University
Target Recruit Count
187
Registration Number
NCT04439474
Locations
🇮🇷

Mohammad Sadegh Bagheri Baghdasht, Tehran, Iran, Islamic Republic of

Cholecalciferol to Improve the Outcomes of COVID-19 Patients

Phase 4
Completed
Conditions
Interventions
First Posted Date
2020-06-02
Last Posted Date
2021-07-30
Lead Sponsor
Vitamin D Study Group
Target Recruit Count
218
Registration Number
NCT04411446
Locations
🇦🇷

Hospital de Alta Complejidad en Red El Cruce, Florencio Varela, Buenos Aires, Argentina

Oral Colecalciferol Treatment in Spinal Cord Lesion

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-05-26
Last Posted Date
2021-02-12
Lead Sponsor
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Target Recruit Count
60
Registration Number
NCT04400747
Locations
🇹🇷

Istanbul Physical Medicine Rehabilitation Training & Research Hospital, İstanbul, Turkey

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