Vitamin D3

A high-protein, high-fiber meal plan supports a healthy menopause transition, focusing on nutrients like protein, fiber, omega-3s, calcium, and magnesium. The 7-day plan includes modifications for 1,500 and 2,000 calories, emphasizing omega-3-rich foods to reduce symptoms and support hormone changes. Each day provides at least 80g of protein and 30g of fiber, with tips for balanced eating, gut health, inflammation reduction, and bone maintenance.

Recent studies in The ASCO Post include: KEYNOTE-522 showing pembrolizumab plus chemotherapy benefits in early-stage triple-negative breast cancer; WHO review finding no link between mobile phone use and brain cancer; TiNivo-2 trial reporting no progression-free survival benefit from nivolumab plus tivozanib in metastatic renal cell carcinoma; SOLARIS trial finding no progression-free survival benefit from high-dose vitamin D3 in metastatic colorectal cancer; American Cancer Society report highlighting rising breast cancer incidence in key subgroups; retrospective study on adjuvant chemotherapy in pancreatic ductal adenocarcinoma; genetic study identifying unique prostate cancer risk factors in African men; and first-in-human trial of puxitatug samrotecan showing manageable safety profile and preliminary efficacy in advanced solid tumors.

A multicenter, single-arm, open-label, phase Ib/II study conducted in China evaluated JMT103 in patients with unresectable or surgically-challenging giant cell tumor of bone (GCTB). The study, approved by ethics committees and registered at ClinicalTrials.gov (NCT04255576), involved 24 centers and administered JMT103 subcutaneously at 2 mg/kg every four weeks. Primary endpoints included histopathological or radiological objective tumor response (OTR), with secondary endpoints covering overall response rate (ORR), disease control rate (DCR), time to progression (TTP), and safety. Statistical analyses were performed using SAS software, with a sample size of 125 patients to ensure a 95% confidence interval for OTR.

Winter increases risk of colds, flu, COVID-19, and RSV due to indoor gatherings and cold, dry conditions. Preventive measures include hand washing, avoiding face touching, adequate sleep, and a healthy diet. Essential vitamins and minerals for immune support include Vitamin A, B9, B12, C, D, iron, and zinc, best obtained through varied food sources. Vitamin D deficiency can increase cold susceptibility, while other deficiencies may cause fatigue, hair loss, or mood disorders.

A review of 25 randomized clinical trials (RCTs) on vitamin D supplementation for COVID-19 highlights inconsistent evidence on its preventive or clinical outcome benefits. The review emphasizes serum 25-hydroxyvitamin D concentration as a key indicator of supplementation effect but notes its unreliability in predicting COVID-19 outcomes.

Tonik, an Australian wellness company, plans to introduce its transdermal patches to China early next year, following successful launches in Hong Kong, the Philippines, and Thailand. The patches, formulated by naturopath Glenn Summerville, offer sleep and stress relief using homeopathic ingredients. Tonik's patches have seen 300% month-on-month sales growth, with the US and Australia as their largest markets. The company aims to educate Chinese consumers about the benefits of transdermal delivery, which bypasses the digestive system, offering a gentler alternative to oral supplements.

Dr. Isaacson Bababode Adelani, a cancer researcher at Johns Hopkins University, focuses on vitamin D's role in liver and prostate cancer, advocating for precision medicine and environmental cancer-causing agent studies, particularly in Africa.

Metabolon releases 'Guide to Multiomics' and webinar, showcasing how integrating genomics, transcriptomics, proteomics, metabolomics, and microbiome studies transforms life science research, exemplified by Crohn's disease studies.

Vitamin D3-loaded ethosomes were prepared using a cold technique with varying soya lecithin concentrations, achieving high entrapment efficiency. The optimal formulation, ED3-7, showed significant drug entrapment and controlled release. Ethosomes demonstrated high skin permeability and were non-irritating to rabbit skin, indicating potential for transdermal delivery.