MedPath

Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Sunshine 2 Study for Women With Diabetes

Phase 2
Completed
Conditions
Diabetes
Quality of Life
Depression
Interventions
Drug: Vitamin D3 comparator
Drug: Vitamin D3
First Posted Date
2013-07-22
Last Posted Date
2022-04-26
Lead Sponsor
Loyola University
Target Recruit Count
265
Registration Number
NCT01904032
Locations
🇺🇸

Loyola University Medical Center, Maywood, Illinois, United States

Cholecalciferol Supplementation on Disease Activity, Fatigue and Bone Mass on Juvenile Systemic Lupus Erythematosus.

Not Applicable
Completed
Conditions
Systemic Lupus Erythematosus
Interventions
First Posted Date
2013-07-04
Last Posted Date
2016-05-12
Lead Sponsor
ROSA MARIA RODRIGUES PEREIRA
Target Recruit Count
60
Registration Number
NCT01892748
Locations
🇧🇷

University of Sao Paulo - School of Medicine, Sao Paulo, Brazil

Effect of Supplementation With Vitamin D on the Acute Bronchitis Prevention During the First Year of Life

Phase 3
Completed
Conditions
Acute Bronchitis
Upper Respiratory Tract Infection
Acute Bronchiolitis
Interventions
Drug: Vitamin D3
Drug: Placebo
First Posted Date
2013-06-12
Last Posted Date
2017-03-22
Lead Sponsor
Hospital Universitari Vall d'Hebron Research Institute
Target Recruit Count
200
Registration Number
NCT01875757
Locations
🇪🇸

Hospital Universitary Vall d'Hebron, Barcelona, Spain

Vitamin D3, Folic Acid and Fexofenadine in Healthy Volunteers

Phase 1
Completed
Conditions
Physiological Effects of Vitamin D
Interventions
First Posted Date
2013-05-17
Last Posted Date
2013-08-13
Lead Sponsor
University of Zurich
Target Recruit Count
10
Registration Number
NCT01856348
Locations
🇨🇭

University Hospital Zurich, Dept. of Clinical Pharmacology and Toxicology, Zurich, ZH, Switzerland

Effects of Treating Vitamin D Deficiency in Poorly Controlled Type 2 Diabetes

Phase 1
Completed
Conditions
Type 2 Diabetes
Interventions
Drug: Placebo
Drug: Vitamin D
First Posted Date
2013-05-16
Last Posted Date
2015-06-26
Lead Sponsor
University of Florida
Target Recruit Count
76
Registration Number
NCT01855321
Locations
🇺🇸

Shands Medical Plaza, Gainesville, Florida, United States

The Effect of Vitamin D Supplementation in Type 2 Diabetes

Phase 4
Completed
Conditions
DIABETES MELLITUS
Interventions
Drug: placebo
Drug: Vitamin D3
First Posted Date
2013-05-15
Last Posted Date
2013-05-15
Lead Sponsor
Chuncheon Sacred Heart Hospital
Target Recruit Count
158
Registration Number
NCT01854463
Locations
🇰🇷

Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-do, Korea, Republic of

Ulcerative Colitis and Vitamin D Supplementation

Phase 1
Withdrawn
Conditions
Ulcerative Colitis
Interventions
Drug: placebo
Drug: Vitamin D
First Posted Date
2013-05-03
Last Posted Date
2015-06-02
Lead Sponsor
University Hospital of North Norway
Registration Number
NCT01846026
Locations
🇳🇴

University Hospital of North Norway, Tromsø, Norway

Phase I Assay-guided Trial of Anti-inflammatory Phytochemicals in Patients With Advanced Cancer

Phase 1
Completed
Conditions
Solid Cancers
Interventions
First Posted Date
2013-03-28
Last Posted Date
2018-05-18
Lead Sponsor
Medical University of South Carolina
Target Recruit Count
22
Registration Number
NCT01820299
Locations
🇺🇸

Medical University of South Carolina, Charleston, South Carolina, United States

Efficacy of Cholecalciferol (Vitamin D3) for Delaying the Diagnosis of MS After a Clinically Isolated Syndrome

Phase 3
Completed
Conditions
Multiple Sclerosis
Interventions
Drug: Placebo
Drug: Vitamin D
Other: Imaging
Biological: Lumbar puncture
Biological: Blood sampling
Biological: Urine samples
First Posted Date
2013-03-22
Last Posted Date
2024-01-12
Lead Sponsor
Centre Hospitalier Universitaire de Nīmes
Target Recruit Count
316
Registration Number
NCT01817166
Locations
🇫🇷

CH de Pau, Pau, France

🇫🇷

CHU d'Amiens - Hôpital Nord, Amiens Cedex 1, France

🇫🇷

CHU de Lyon - Hôpital Pierre Wertheimer, Bron, France

and more 30 locations

Placebo-controlled Trial With Vitamin D to Prevent Worsening/Relieve Aromatase Inhibitor-induced Musculoskeletal Symptoms in Breast Cancer Patients

Phase 2
Terminated
Conditions
Breast Cancer
Musculoskeletal Disease
Interventions
Drug: Placebo
Drug: Vitamin D3
First Posted Date
2013-03-12
Last Posted Date
2015-10-21
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
15
Registration Number
NCT01809171
Locations
🇧🇪

University Hospitals Leuven, Leuven, Belgium

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