Somatotropin
- Generic Name
- Somatotropin
- Brand Names
- Genotropin, Humatrope, Norditropin, Norditropin Nordiflex, Nutropin, Nutropinaq, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, NutropinAq
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 12629-01-5
- Unique Ingredient Identifier
- NQX9KB6PCL
- Background
Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland. Growth hormone plays an essential role in growth regulation during childhood as well as other basal metabolic functions, muscle and fat mass regulation, blood glucose level regulation, and li...
- Indication
Somatotropin is indicated for the treatment of pediatric patients who have growth failure due to an inadequate secretion of endogenous growth hormone, short stature associated with Turner syndrome, Prader-Willi syndrome (PWS), idiopathic short stature (ISS), short stature or growth failure in short stature homeobox-containing gene (SHOX) deficiency, and shor...
- Associated Conditions
- Adult Onset Growth Hormone Deficiency, Cachexia, Childhood-onset Growth Hormone Deficiency, Growth Failure, HIV Wasting Syndrome, Short Bowel Syndrome (SBS), Short Stature
- Associated Therapies
- -
A Phase 2 Basket Study of Vosoritide in Children with Turner Syndrome, SHOX Deficiency and Noonan Syndrome with an Inadequate Response to Human Growth Hormone
- Conditions
- Interventions
- First Posted Date
- 2024-10-31
- Last Posted Date
- 2024-10-31
- Lead Sponsor
- BioMarin Pharmaceutical
- Target Recruit Count
- 72
- Registration Number
- NCT06668805
A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature
- Conditions
- Interventions
- First Posted Date
- 2024-04-24
- Last Posted Date
- 2024-12-06
- Lead Sponsor
- BioMarin Pharmaceutical
- Target Recruit Count
- 100
- Registration Number
- NCT06382155
- Locations
- 🇺🇸
Centricity Research, Columbus, Georgia, United States
🇺🇸St. Luke's Children's Endocrinology, Boise, Idaho, United States
Human Growth Hormone Injections in the Knee Joint to Treat Osteoarthritis
- First Posted Date
- 2024-04-09
- Last Posted Date
- 2024-10-04
- Lead Sponsor
- John Sledge
- Target Recruit Count
- 23
- Registration Number
- NCT06354023
- Locations
- 🇺🇸
BioShift Life Sciences, Santa Monica, California, United States
Dexamethasone/Pancreatic Clamp P&F
- Conditions
- Interventions
- Drug: Insulin humanDrug: Octreotide AcetateDrug: GlucagonDrug: Human Growth HormoneDrug: Dexamethasone OralOther: [6,6-2H2] D-glucoseDrug: 20% D-glucose (aq)Dietary Supplement: BOOST PlusDevice: Harvard Apparatus PHD ULTRA CP syringe pumpDevice: Yellow Springs Instruments (YSI) 2500 Biochemistry Glucose/Lactate AnalyzerOther: Normal salineOther: Human albumin
- First Posted Date
- 2023-11-13
- Last Posted Date
- 2024-07-10
- Lead Sponsor
- Columbia University
- Registration Number
- NCT06126354
- Locations
- 🇺🇸
Columbia University Irving Medical Center, New York, New York, United States
Randomized Clinical Trial of Two Different Initial Growth Hormone Doses in Children
- Conditions
- Interventions
- First Posted Date
- 2023-10-26
- Last Posted Date
- 2023-12-13
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 50
- Registration Number
- NCT06103513
- Locations
- 🇺🇸
Northwell Health, New York, New York, United States
The Effect of Myo-inositol, Somatropin, and DHEA on Poor Ovarian Responders
- Conditions
- Interventions
- First Posted Date
- 2023-06-12
- Last Posted Date
- 2023-07-18
- Lead Sponsor
- Beni-Suef University
- Target Recruit Count
- 300
- Registration Number
- NCT05900661
- Locations
- 🇪🇬
Beni-suef university Hospital, Banī Suwayf, Beni Suef, Egypt
A Trial of YPEG-rhGH in Children With Short Stature
- Conditions
- Interventions
- First Posted Date
- 2023-05-03
- Last Posted Date
- 2024-01-24
- Lead Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
- Target Recruit Count
- 78
- Registration Number
- NCT05838885
- Locations
- 🇨🇳
The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
🇨🇳The Second Hospital of Anhui Medical University, Hefei, Anhui, China
🇨🇳Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Vesiculogenesis in Children With GH Deficiency (VESCIGHTP)
- First Posted Date
- 2023-03-08
- Last Posted Date
- 2024-10-02
- Lead Sponsor
- Istituto Auxologico Italiano
- Target Recruit Count
- 10
- Registration Number
- NCT05759624
- Locations
- 🇮🇹
Istituto Auxologico Italiano IRCCS, Milan, Italy
A Trial to Investigate Different Doses of Lonapegsomatropin Compared to Somatropin in Individuals With Turner Syndrome
- Conditions
- Interventions
- First Posted Date
- 2023-01-19
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- Ascendis Pharma Endocrinology Division A/S
- Target Recruit Count
- 48
- Registration Number
- NCT05690386
- Locations
- 🇺🇸
Ascendis Pharma Investigational Site, Seattle, Washington, United States
Effects of GH and Lirglutide on AgRP
- Conditions
- Interventions
- First Posted Date
- 2023-01-12
- Last Posted Date
- 2024-01-05
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 40
- Registration Number
- NCT05681299
- Locations
- 🇺🇸
Neuroendocrine Unit and Pituitary Center, Columbia University Irving Medical Center, New York, New York, United States
Drug Development Updates
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