Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Comparison of the Efficacy of Irrigation With Epinephrine or Tranexamic Acid on Visual Clarity
- Conditions
- Interventions
- First Posted Date
- 2020-11-13
- Last Posted Date
- 2020-11-13
- Lead Sponsor
- Haseki Training and Research Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT04628676
- Locations
- 🇹🇷
Haseki Training and Research Hospital, Istanbul, Turkey
Perioperative Management in Gynaecological Carcinoma Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-11-12
- Last Posted Date
- 2024-03-01
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 126
- Registration Number
- NCT04625530
- Locations
- 🇨🇭
Department of Obstetrics and Gynaecology, University Hospital Basel, Basel, Switzerland
The Effect of Tranexamic Acid (TXA) on Visualization During Shoulder Arthroscopy
- Conditions
- Interventions
- First Posted Date
- 2020-10-30
- Last Posted Date
- 2020-10-30
- Lead Sponsor
- Rothman Institute Orthopaedics
- Target Recruit Count
- 200
- Registration Number
- NCT04610164
- Locations
- 🇺🇸
Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States
Evaluation of Laser and Tranexamic Acid in Treatment of Melasma
- First Posted Date
- 2020-10-22
- Last Posted Date
- 2020-10-22
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 40
- Registration Number
- NCT04599205
The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection
- Conditions
- Interventions
- First Posted Date
- 2020-10-22
- Last Posted Date
- 2023-01-04
- Lead Sponsor
- Beijing Tiantan Hospital
- Target Recruit Count
- 600
- Registration Number
- NCT04595786
- Locations
- 🇨🇳
Beijing Tiantan Hospital, Beijing, Beijing, China
Tranexamic Acid to Improve Arthroscopic Visualization in Shoulder Surgery
- First Posted Date
- 2020-10-20
- Last Posted Date
- 2024-04-02
- Lead Sponsor
- Panam Clinic
- Target Recruit Count
- 128
- Registration Number
- NCT04594408
- Locations
- 🇨🇦
Pan Am Clinic, Winnipeg, Manitoba, Canada
Efficacy of Tranexamic Acid in Reducing Myomectomy Associated Blood Loss in Federal Teaching Hospital Abakaliki.
- Conditions
- Interventions
- First Posted Date
- 2020-09-23
- Last Posted Date
- 2020-09-23
- Target Recruit Count
- 59
- Registration Number
- NCT04560465
- Locations
- 🇳🇬
AEFUTHA, Abakaliki, Ebonyi, Nigeria
Intravesical Antifibrinolytic for Patients With Hematuria and Clot Retention
- Conditions
- Interventions
- First Posted Date
- 2020-09-18
- Last Posted Date
- 2021-11-05
- Lead Sponsor
- Fraser Health
- Target Recruit Count
- 14
- Registration Number
- NCT04555343
- Locations
- 🇨🇦
Royal Columbian Hospital, New Westminster, British Columbia, Canada
🇨🇦Eagle Ridge Hospital, Port Moody, British Columbia, Canada
Antiviral Effects of TXA as a Preventative Treatment Following COVID-19 Exposure
- First Posted Date
- 2020-09-16
- Last Posted Date
- 2021-04-23
- Lead Sponsor
- University of Alabama at Birmingham
- Registration Number
- NCT04550338
Determination of Blood Loss After CS
- First Posted Date
- 2020-09-16
- Last Posted Date
- 2020-09-16
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 130
- Registration Number
- NCT04549012
Drug Development Updates
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