Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Topical Tranexamic Acid Use on Granulating Wounds Following Mohs Micrographic Surgery
- Conditions
- Interventions
- First Posted Date
- 2020-09-09
- Last Posted Date
- 2024-11-21
- Lead Sponsor
- University of Missouri-Columbia
- Target Recruit Count
- 124
- Registration Number
- NCT04541303
- Locations
- 🇺🇸
University of Missouri-Columbia, Columbia, Missouri, United States
Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations
- First Posted Date
- 2020-09-03
- Last Posted Date
- 2020-09-03
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 90
- Registration Number
- NCT04537533
Bakri Balloon Plus Tranexamic Acid During Cesarean Delivery for Placenta Previa
- Conditions
- Interventions
- First Posted Date
- 2020-08-19
- Last Posted Date
- 2020-09-21
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 140
- Registration Number
- NCT04518163
- Locations
- 🇪🇬
Aswan University Hospital, Aswan, Egypt
Effect of Perioperative Tranexamic Acid on Blood Loss During Management of Maxillofacial Trauma
- First Posted Date
- 2020-07-31
- Last Posted Date
- 2021-08-03
- Target Recruit Count
- 200
- Registration Number
- NCT04494126
Blood Loss After Early TXA in Hip Fractures.
- First Posted Date
- 2020-07-28
- Last Posted Date
- 2022-07-19
- Lead Sponsor
- Community Memorial Health System
- Target Recruit Count
- 120
- Registration Number
- NCT04488367
- Locations
- 🇺🇸
Community Memorial Hospital, Ventura, California, United States
Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis
- Conditions
- Interventions
- First Posted Date
- 2020-07-28
- Last Posted Date
- 2022-01-31
- Lead Sponsor
- Institute of Liver and Biliary Sciences, India
- Target Recruit Count
- 600
- Registration Number
- NCT04489108
- Locations
- 🇮🇳
Institute of Liver & Biliary Sciences, New Delhi, Delhi, India
Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial)
- First Posted Date
- 2020-06-25
- Last Posted Date
- 2023-09-21
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 662
- Registration Number
- NCT04448184
- Locations
- 🇨🇦
Dalhousie University, Halifax, Nova Scotia, Canada
🇨🇦Memorial University, St. John's, Newfoundland and Labrador, Canada
🇨🇦Eastern Regional Health Authority, Saint John's, Newfoundland and Labrador, Canada
Use of Tranexamic Acid in Liposculpture
- First Posted Date
- 2020-06-12
- Last Posted Date
- 2020-06-12
- Lead Sponsor
- Total Definer Research Group
- Target Recruit Count
- 141
- Registration Number
- NCT04430777
- Locations
- 🇨🇴
Dhara clinic, Bogota, Colombia
🇲🇽Innovare hospital, Jalisco, Mexico
🇲🇽Centro Medico de las Americas clinic, Merida, Mexico
Tranexamic Acid in the Prevention of Postpartum Hemorrhage in Elective Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2020-06-11
- Last Posted Date
- 2022-11-09
- Lead Sponsor
- KK Women's and Children's Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT04427618
- Locations
- 🇸🇬
KK Women's and Children's Hospital, Singapore, Singapore
The Effect of Intravenous Tranexamic Acid and Interscalene Block Applied on Shoulder Arthroscopy
- Conditions
- Interventions
- First Posted Date
- 2020-06-05
- Last Posted Date
- 2020-06-09
- Target Recruit Count
- 60
- Registration Number
- NCT04419246
Drug Development Updates
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