Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
- First Posted Date
- 2018-03-13
- Last Posted Date
- 2022-06-01
- Lead Sponsor
- University of Zimbabwe
- Target Recruit Count
- 506
- Registration Number
- NCT03463993
- Locations
- 🇿🇼
Parirenyatwa Group of Hospitals, Harare, Zimbabwe
🇿🇼Harare Central Hospital, Harare, Zimbabwe
Tranexamic Acid for the Latarjet Procedure.
- Conditions
- Interventions
- First Posted Date
- 2018-03-08
- Last Posted Date
- 2019-07-30
- Lead Sponsor
- Sports Surgery Clinic, Santry, Dublin
- Target Recruit Count
- 100
- Registration Number
- NCT03458468
- Locations
- 🇮🇪
Sports Surgery Clinic, Santry, Dublin, Ireland
Efficacy and Safety of Tranexamic Acid in Spinal Fusion Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-02-08
- Last Posted Date
- 2021-06-21
- Lead Sponsor
- Exela Pharma Sciences, LLC.
- Target Recruit Count
- 5
- Registration Number
- NCT03425799
- Locations
- 🇺🇸
Spine Care Orthopedics - NYU Lagone Medical Center, New York, New York, United States
🇺🇸Memorial Orthopaedic Surgery Group, Long Beach, California, United States
🇺🇸Cedars-Sinai Medical Center, Los Angeles, California, United States
Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction
- First Posted Date
- 2018-01-29
- Last Posted Date
- 2024-08-01
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 222
- Registration Number
- NCT03413891
- Locations
- 🇧🇪
University Hospitals Leuven, Leuven, Belgium
STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units
- Conditions
- Interventions
- First Posted Date
- 2017-12-29
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- Neuroscience Trials Australia
- Target Recruit Count
- 201
- Registration Number
- NCT03385928
- Locations
- 🇦🇺
Box Hill Hospital, Box Hill, Victoria, Australia
🇦🇺Monash Medical Centre, Clayton, Victoria, Australia
🇦🇺Royal Adelaide Hospital, Adelaide, South Australia, Australia
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
- First Posted Date
- 2017-12-18
- Last Posted Date
- 2021-02-11
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 97
- Registration Number
- NCT03376061
- Locations
- 🇨🇦
Hamilton General Hospital, Hamilton, Ontario, Canada
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean
- Conditions
- Interventions
- First Posted Date
- 2017-12-06
- Last Posted Date
- 2023-02-21
- Target Recruit Count
- 11000
- Registration Number
- NCT03364491
- Locations
- 🇺🇸
Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
🇺🇸Magee Women's Hospital of UPMC, Pittsburgh, Pennsylvania, United States
🇺🇸University of Texas - Houston, Houston, Texas, United States
Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris
- Conditions
- Interventions
- First Posted Date
- 2017-12-04
- Last Posted Date
- 2023-05-16
- Lead Sponsor
- Wayne State University
- Registration Number
- NCT03361345
- Locations
- 🇺🇸
WSUPG Dermatology, Dearborn, Michigan, United States
Study Comparing Topical Versus Intravenous Tranexamic Acid in Anterior Total Hip Arthroplasty
- First Posted Date
- 2017-12-02
- Last Posted Date
- 2017-12-02
- Lead Sponsor
- Albany Medical College
- Target Recruit Count
- 114
- Registration Number
- NCT03359525
- Locations
- 🇺🇸
Albany Medical Center, Albany, New York, United States
Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis
- Conditions
- Interventions
- First Posted Date
- 2017-12-02
- Last Posted Date
- 2018-08-07
- Lead Sponsor
- Kecioren Education and Training Hospital
- Target Recruit Count
- 135
- Registration Number
- NCT03360045
- Locations
- 🇹🇷
Keçiören Training and Research Hospital, Ankara, Turkey
Drug Development Updates
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