Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Low vs. Very Low Dose of Prophylactic Tranexamic Acid for Bleeding Reduction During Rhinoplasty
- First Posted Date
- 2017-03-06
- Last Posted Date
- 2017-08-30
- Lead Sponsor
- Bartłomiej Wódarski
- Target Recruit Count
- 50
- Registration Number
- NCT03070847
- Locations
- 🇵🇱
Samodzielny Publiczny Szpital Kliniczny im. prof. W. Orłowskiego w Warszawie, Warsaw, Mazowieckie, Poland
Tranexamic Acid Use in Elective Cesarean Section for Women With Placenta Previa
- First Posted Date
- 2017-02-23
- Last Posted Date
- 2017-02-23
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 86
- Registration Number
- NCT03060889
Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty
- First Posted Date
- 2017-02-06
- Last Posted Date
- 2018-01-30
- Lead Sponsor
- Thammasat University
- Target Recruit Count
- 80
- Registration Number
- NCT03044041
- Locations
- 🇹🇭
Thammasat University, Klong Luang, Pathum Thani, Thailand
Tranexamic Acid for Spontaneous Acute Cerebral Hemorrhage Trial
- First Posted Date
- 2017-02-06
- Last Posted Date
- 2019-10-17
- Lead Sponsor
- Kwong Wah Hospital
- Target Recruit Count
- 220
- Registration Number
- NCT03044184
- Locations
- 🇭🇰
Kwong Wah Hospital, Hong Kong, Hong Kong
Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery
- First Posted Date
- 2017-01-31
- Last Posted Date
- 2024-02-20
- Lead Sponsor
- Henry Ford Health System
- Target Recruit Count
- 83
- Registration Number
- NCT03037515
- Locations
- 🇺🇸
Henry Ford Health System, Detroit, Michigan, United States
Efficacity and Safety of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding
- First Posted Date
- 2017-01-18
- Last Posted Date
- 2018-04-11
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 500
- Registration Number
- NCT03023189
- Locations
- 🇫🇷
Jean Verdier Hospital, Bondy, France
🇫🇷Marc Jacquet Hospital, Melun, France
🇫🇷Henri Mondor Hospital, Creteil, France
Topical Tranexamic Acid (TXA) in Hip Fractures
- First Posted Date
- 2016-12-15
- Last Posted Date
- 2019-08-19
- Lead Sponsor
- Sault Area Hospital
- Target Recruit Count
- 65
- Registration Number
- NCT02993341
- Locations
- 🇨🇦
Sault Area Hospital, Sault Ste. Marie, Ontario, Canada
HiFIT Study : Hip Fracture: Iron and Tranexamic Acid
- Conditions
- Interventions
- First Posted Date
- 2016-11-23
- Last Posted Date
- 2022-08-02
- Lead Sponsor
- University Hospital, Angers
- Target Recruit Count
- 419
- Registration Number
- NCT02972294
- Locations
- 🇫🇷
Chu Grenoble - Departement D'Anesthesie Reanimation, Grenoble, France
🇫🇷CHD Vendée, La Roche-sur-Yon, France
🇫🇷Hospices Civils Lyon, Lyon, France
Impact of Tranexamic Acid Use in Percutaneous Nephrolithotomy
- First Posted Date
- 2016-11-17
- Last Posted Date
- 2018-05-31
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 192
- Registration Number
- NCT02966236
- Locations
- 🇧🇷
University of Sao Paulo Medical School, Sao Paulo, Brazil
Tranexamic Acid Use in Acute Hip Fractures
- First Posted Date
- 2016-10-28
- Last Posted Date
- 2023-02-21
- Lead Sponsor
- Carilion Clinic
- Target Recruit Count
- 113
- Registration Number
- NCT02947529
- Locations
- 🇺🇸
Carilion Roanoke Memorial Hospital, Roanoke, Virginia, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.