Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Ulipristal Use in Chinese Population
- Conditions
- Interventions
- First Posted Date
- 2016-07-07
- Last Posted Date
- 2020-04-09
- Lead Sponsor
- Queen Mary Hospital, Hong Kong
- Target Recruit Count
- 31
- Registration Number
- NCT02825719
- Locations
- 🇭🇰
Department of Obstetrics and Gynaecology, Queen Mary Hospital, Hong Kong, Hong Kong
Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study
- Conditions
- Interventions
- First Posted Date
- 2016-06-20
- Last Posted Date
- 2019-12-03
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 14
- Registration Number
- NCT02806024
- Locations
- 🇺🇸
Community Regional Medical Center, Fresno, California, United States
Effectiveness of Tranexamic Acid When Used as an Adjunct to Misoprostol for the Treatment of Postpartum Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2016-06-20
- Last Posted Date
- 2018-02-19
- Lead Sponsor
- Gynuity Health Projects
- Target Recruit Count
- 260
- Registration Number
- NCT02805426
- Locations
- 🇻🇳
Hung Vuong Hospital, Ho Chi Minh City, Vietnam
🇸🇳Centre hospitalier Régional de Thiès, Ahmadou Sakhir Ndiéguène, Thiès, Senegal
🇻🇳National OB-GYN Hospital, Hanoi, Vietnam
Efficacy of Tranexamic Acid in Hemoptysis
- First Posted Date
- 2016-05-24
- Last Posted Date
- 2016-05-24
- Target Recruit Count
- 66
- Registration Number
- NCT02781597
- Locations
- 🇮🇳
Post graduate institute of medical education and research, Chandigarh, UT, India
Role of Tranexamic Acid Versus Uterine Cooling at Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2016-05-23
- Last Posted Date
- 2016-09-05
- Lead Sponsor
- Talkha Central Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT02780245
- Locations
- 🇪🇬
Talkha Central Hospital, Mansoura, Al-Dakahliya, Egypt
Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH
- First Posted Date
- 2016-05-18
- Last Posted Date
- 2024-02-08
- Lead Sponsor
- Azienda U.S.L. 1 di Massa e Carrara
- Target Recruit Count
- 256
- Registration Number
- NCT02775773
- Locations
- 🇮🇹
Department of Ostetricia e Ginecologia-Ospedale delle Apuane, Massa, MS, Italy
TXA Study in Major Burn Surgery
- Conditions
- Interventions
- First Posted Date
- 2016-04-28
- Last Posted Date
- 2021-08-23
- Lead Sponsor
- Spectrum Health Hospitals
- Target Recruit Count
- 25
- Registration Number
- NCT02753816
- Locations
- 🇺🇸
Spectrum Health Hospital, Grand Rapids, Michigan, United States
Role Of Different Prophylactic Doses Of Intravenous Tranexamic Acid In Reducing Blood Loss At Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2016-04-15
- Last Posted Date
- 2016-06-15
- Lead Sponsor
- Talkha Central Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT02739815
- Locations
- 🇪🇬
Al-Azhar University, Faculty of Medicine for Boys ( Cairo ), Al-Hussein University Hospital, Cairo, Egypt
Effects of Tranexamic Acid on Blood Loss and Transfusion Requirement Following Hip Fracture
- First Posted Date
- 2016-04-14
- Last Posted Date
- 2016-04-14
- Lead Sponsor
- Rothman Institute Orthopaedics
- Registration Number
- NCT02738073
- Locations
- 🇺🇸
Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States
Intravenous Tranexamic Acid Versus Pericervical Tourniquet To Decrease Blood Loss In Trans-Abdominal Myomectomy
- Conditions
- Interventions
- First Posted Date
- 2016-04-12
- Last Posted Date
- 2016-04-12
- Lead Sponsor
- Ain Shams Maternity Hospital
- Target Recruit Count
- 70
- Registration Number
- NCT02733952
- Locations
- 🇪🇬
Ain shams university maternity hospital, Cairo, Egypt
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.