Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
American Trial Using Tranexamic Acid in Thrombocytopenia
- First Posted Date
- 2015-10-19
- Last Posted Date
- 2021-03-24
- Lead Sponsor
- University of Washington
- Target Recruit Count
- 330
- Registration Number
- NCT02578901
- Locations
- 🇺🇸
University of Washington, Seattle, Washington, United States
🇺🇸University of North Carolina, Chapel Hill, North Carolina, United States
🇺🇸University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Investigation of Intravenous Tranexamic Acid With Anatomic and Reverse Total Shoulder Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2015-10-07
- Last Posted Date
- 2021-11-02
- Lead Sponsor
- Rush University Medical Center
- Target Recruit Count
- 110
- Registration Number
- NCT02569658
- Locations
- 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
Tranexamic Acid in Chronic Subdural Hematomas
- First Posted Date
- 2015-10-05
- Last Posted Date
- 2023-09-05
- Target Recruit Count
- 130
- Registration Number
- NCT02568124
- Locations
- 🇨🇦
University of Alberta Hospital, Edmonton, Alberta, Canada
🇨🇦Centre Hospitalier Affilié Universitaire de Québec, Québec, Canada
🇨🇦Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada
A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2015-09-28
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- Janssen Scientific Affairs, LLC
- Target Recruit Count
- 158
- Registration Number
- NCT02561923
PeriOperative ISchemic Evaluation-3 Trial: A Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2015-09-11
- Last Posted Date
- 2018-04-24
- Lead Sponsor
- McMaster University
- Target Recruit Count
- 100
- Registration Number
- NCT02546648
- Locations
- 🇨🇦
Juravinski Hospital, Hamilton, Ontario, Canada
🇨🇦Hamilton General Hospital, Hamilton, Ontario, Canada
Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
- Conditions
- Interventions
- First Posted Date
- 2015-08-31
- Last Posted Date
- 2021-08-31
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 150
- Registration Number
- NCT02535949
- Locations
- 🇺🇸
Barnes Jewish Hospital, Saint Louis, Missouri, United States
The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty
- First Posted Date
- 2015-07-21
- Last Posted Date
- 2016-03-04
- Lead Sponsor
- Xijing Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT02504125
- Locations
- 🇨🇳
Xijing hospital, Xi'an, Shaanxi, China
Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH (TRANOXY2015)
- First Posted Date
- 2015-07-20
- Last Posted Date
- 2024-02-08
- Lead Sponsor
- Azienda U.S.L. 1 di Massa e Carrara
- Registration Number
- NCT02503319
Evaluation of Intraarticular Tranexamic Acid to Reduction of Total Blood Loss Following Knee-Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2015-04-28
- Last Posted Date
- 2015-08-17
- Lead Sponsor
- Hvidovre University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT02427412
- Locations
- 🇩🇰
Hvidovre University Hospital, Hvidovre, Denmark
Acid Tranexamic Effectiveness in Reducing the Intraoperative Bleeding in Palatoplasty
- First Posted Date
- 2015-04-21
- Last Posted Date
- 2015-04-21
- Target Recruit Count
- 66
- Registration Number
- NCT02422056
Drug Development Updates
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