Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty
- First Posted Date
- 2014-11-10
- Last Posted Date
- 2014-11-10
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 264
- Registration Number
- NCT02286973
Effectiveness of Intravenous Tranexamic Acid in Reducing Blood Loss During and After Cesarean Section
- First Posted Date
- 2014-10-30
- Last Posted Date
- 2014-11-04
- Lead Sponsor
- Ain Shams Maternity Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT02279186
- Locations
- 🇪🇬
Ain Shams Maternity Hospital, Cairo, Egypt
Tranexamic Acid in Knee Joint Surgery
- Conditions
- Interventions
- First Posted Date
- 2014-10-29
- Last Posted Date
- 2020-05-20
- Target Recruit Count
- 150
- Registration Number
- NCT02278263
- Locations
- 🇳🇿
Auckland Hospital, Auckland, New Zealand
🇳🇿Manukau Surgery Centre, Auckland, New Zealand
🇳🇿North Shore Hospital, Auckland, New Zealand
Efficacy of Tranexamic Acid for Reducing Blood Loss and Blood Transfusion After Periacetabular Osteotomy
- Conditions
- Interventions
- First Posted Date
- 2014-10-01
- Last Posted Date
- 2022-11-25
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 89
- Registration Number
- NCT02253810
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Prevention of Intraoperative Bleeding and Postoperative Swelling in Orthognathic Surgery Through the Use of Tranexamic Acid
- Conditions
- Interventions
- First Posted Date
- 2014-09-01
- Last Posted Date
- 2017-03-10
- Target Recruit Count
- 104
- Registration Number
- NCT02229292
- Locations
- 🇩🇰
Hospital of South West Denmark, Esbjerg, Denmark
Topical Instillation of Tranexamic Aacid in Bronchoscopy to Decrease Bleeding During Entobronchial & Transbronchial Biopsiy: a Prospective Double Blind Placebo Controlled Study
- First Posted Date
- 2014-08-18
- Last Posted Date
- 2018-06-01
- Lead Sponsor
- Liran Levy
- Target Recruit Count
- 120
- Registration Number
- NCT02219152
- Locations
- 🇮🇱
Hadassah Medical Organization, Jerusalem, Israel
Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)
- Conditions
- Interventions
- First Posted Date
- 2014-07-10
- Last Posted Date
- 2023-01-27
- Lead Sponsor
- Monash University
- Target Recruit Count
- 1310
- Registration Number
- NCT02187120
- Locations
- 🇦🇺
South Australia Ambulance Service, Eastwood, South Australia, Australia
🇳🇿St John Ambulance, Albany, New Zealand
🇦🇺NNSW Medical Retrieval Service, Lismore, New South Wales, Australia
Effect of Tranexamic Acid Based on Pharmacokinetics in Pediatric Patients Undergoing Craniosynostosis Surgery: Randomized Controlled Trial
- Conditions
- Interventions
- First Posted Date
- 2014-07-02
- Last Posted Date
- 2016-04-12
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 50
- Registration Number
- NCT02180321
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of
Postoperative Bleeding Prevention in Massive Bone Tumour Resection
- Conditions
- Interventions
- First Posted Date
- 2014-06-03
- Last Posted Date
- 2016-09-20
- Target Recruit Count
- 56
- Registration Number
- NCT02153593
- Locations
- 🇪🇸
Hospital Universitario de San Juan de Alicante, Alicante, Spain
🇪🇸Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
🇪🇸Hospital Universitario de Cruces, Barakaldo,, Vizcaya, Spain
Comparison of Floseal® and Tranexamic Acid on Bleeding Control After Total Knee Arthroplasty
- First Posted Date
- 2014-06-02
- Last Posted Date
- 2014-06-02
- Lead Sponsor
- University of Sao Paulo General Hospital
- Target Recruit Count
- 45
- Registration Number
- NCT02152917
- Locations
- 🇧🇷
Hospital das Clinicas - University of Sao Paulo, Sao Paulo, Brazil
Drug Development Updates
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