Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2023-09-05
- Last Posted Date
- 2023-11-01
- Target Recruit Count
- 150
- Registration Number
- NCT06023212
- Locations
- 🇨🇳
the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects
- Conditions
- Interventions
- First Posted Date
- 2023-08-21
- Last Posted Date
- 2024-04-03
- Lead Sponsor
- Oregon Health and Science University
- Target Recruit Count
- 48
- Registration Number
- NCT06000423
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
Tranexamic Acid Dose and Confusion After Cardiac Surgery
- Conditions
- First Posted Date
- 2023-07-28
- Last Posted Date
- 2023-07-28
- Lead Sponsor
- Papworth Hospital NHS Foundation Trust
- Target Recruit Count
- 5000
- Registration Number
- NCT05966012
- Locations
- 🇬🇧
Royal Papworth Hospital NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom
Goal-directed vs Preemptive Tranexamic Acid Administration in Total Hip Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2023-07-21
- Last Posted Date
- 2024-01-02
- Lead Sponsor
- Konkuk University Medical Center
- Target Recruit Count
- 84
- Registration Number
- NCT05956769
- Locations
- 🇰🇷
Soi Lee, Seoul, Korea, Republic of
🇰🇷Konkuk University Medical Center, Seoul, Korea, Republic of
Tranexamic Acid in Percutaneous Nephrolithotomy
- Conditions
- Interventions
- First Posted Date
- 2023-07-17
- Last Posted Date
- 2023-07-19
- Lead Sponsor
- Haseki Training and Research Hospital
- Target Recruit Count
- 75
- Registration Number
- NCT05947435
- Locations
- 🇹🇷
Haseki Training and Research Hospital, Istanbul, Sultangazi, Turkey
Tranexamic Acid in Breast Esthetic Surgery.
- First Posted Date
- 2023-07-14
- Last Posted Date
- 2023-10-13
- Lead Sponsor
- Poznan University of Medical Sciences
- Target Recruit Count
- 60
- Registration Number
- NCT05945680
- Locations
- 🇵🇱
Poznan University of Medical Sciences, Poznań, Poland
Do Patients Who Received Tranexamic Acid in Vaginal Hysterectomy Loose Les Blood, Comparing to Patients Who Did Not?
- Conditions
- Interventions
- First Posted Date
- 2023-06-27
- Last Posted Date
- 2024-04-23
- Lead Sponsor
- Wolfson Medical Center
- Target Recruit Count
- 80
- Registration Number
- NCT05921071
- Locations
- 🇮🇱
Wolfson medical center, H̱olon, Israel
Perioperative Treatment With Tranexamic Acid in Melanoma
- First Posted Date
- 2023-06-12
- Last Posted Date
- 2024-01-19
- Lead Sponsor
- University of Aarhus
- Target Recruit Count
- 1204
- Registration Number
- NCT05899465
- Locations
- 🇩🇰
Aarhus University Hospital, Aarhus, Central Denmark Region, Denmark
🇩🇰Aalborg University Hospital, Aalborg, North Denmark Region, Denmark
Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma
- First Posted Date
- 2023-06-01
- Last Posted Date
- 2023-06-01
- Lead Sponsor
- Combined Military Hospital Abbottabad
- Target Recruit Count
- 60
- Registration Number
- NCT05884151
- Locations
- 🇵🇰
Dr sana aslam, Abbottabad, Khyber Pakhtun Khwaa, Pakistan
🇵🇰Sana aslam, Abbottābād, Khyber Pakhtun Khwa, Pakistan
Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements
- Conditions
- Interventions
- First Posted Date
- 2023-05-11
- Last Posted Date
- 2023-05-11
- Lead Sponsor
- Instituto Mexicano del Seguro Social
- Target Recruit Count
- 20
- Registration Number
- NCT05855590
- Locations
- 🇲🇽
Centro Médico Nacional de Occidente, Guadalajara, Jalisco, Mexico
Drug Development Updates
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