Overview
Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in presence of Trypsin. Chymotrypsin is the most abundant pancreatic proteases that represent up to 10-20% of the total protein synthesized by the exocrine pancreas . Chymotrypsin contains both the catalytic triad and oxyanion hole, and the tertiary structure of chymotrypsin is similar to Trypsin .
Background
Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chymotrypsin is activated from its inactive zymogen precursor, chymotrypsinogen, in presence of Trypsin. Chymotrypsin is the most abundant pancreatic proteases that represent up to 10-20% of the total protein synthesized by the exocrine pancreas . Chymotrypsin contains both the catalytic triad and oxyanion hole, and the tertiary structure of chymotrypsin is similar to Trypsin .
Indication
No therapeutic indications.
Associated Conditions
- Colorectal Cancer
- Head & Neck Squamous Cell Carcinoma
- Locally Advanced Cervical Cancer
- Locally Advanced Non-Small Cell Lung Cancer
- Multiple Myeloma (MM)
- Primary Non-metastatic Breast Cancer
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/17 | Phase 2 | Recruiting | |||
2024/12/03 | Not Applicable | Recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Chymotrypsin for Injection | 国药准字H22022843 | 化学药品 | 注射剂(冻干) | 9/28/2020 | |
| Chymotrypsin for Injection | 国药准字H22023481 | 化学药品 | 注射剂（冻干） | 3/11/2022 | |
| Chymotrypsin for Injection | 国药准字H11022351 | 化学药品 | 注射剂(冻干粉针剂) | 9/16/2020 | |
| Chymotrypsin for Injection | 国药准字H31022112 | 化学药品 | 注射剂(冻干) | 6/5/2020 | |
| Chymotrypsin for Injection | 国药准字H22023479 | 化学药品 | 注射剂（冻干） | 3/11/2022 | |
| Chymotrypsin for Injection | 国药准字H31022113 | 化学药品 | 注射剂(冻干) | 6/5/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||