Flumazenil
- Generic Name
- Flumazenil
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C15H14FN3O3
- CAS Number
- 78755-81-4
- Unique Ingredient Identifier
- 40P7XK9392
- Background
Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system.
- Indication
For the complete or partial reversal of the sedative effects of benzodiazepines in cases where general anesthesia has been induced and/or maintained with benzodiazepines, and where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Also for the management of benzodiazepine overdose as an adjunct for appropriate support...
- Associated Conditions
- Sedation caused by benzodiazepine
- Associated Therapies
- Anesthesia, Reversal, Reversal of sedation therapy
Finding ED90 of Flumazenil for Selective Improvement of Respiratory Distress by Remimazolam
- First Posted Date
- 2024-08-20
- Last Posted Date
- 2024-08-20
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 60
- Registration Number
- NCT06563063
- Locations
- 🇰🇷
Severance hospital, Seoul, Korea, Republic of
Comparison of Remimazolam and Propofol on Emergence in Elderly Orthopedic Patients Under General Anesthesia
- First Posted Date
- 2024-07-22
- Last Posted Date
- 2024-07-24
- Lead Sponsor
- Central South University
- Target Recruit Count
- 136
- Registration Number
- NCT06513923
- Locations
- 🇨🇳
Department of Anesthesiology, The Second Xiangya Hospital, Changsha, Hunan, China
🇨🇳The Second Xiangya Hospital, Changsha, Hunan, China
Effect of Remazolam on Anesthesia Recovery in Patients Undergoing Fundus Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-01-16
- Last Posted Date
- 2024-05-20
- Lead Sponsor
- Sichuan Provincial People's Hospital
- Target Recruit Count
- 93
- Registration Number
- NCT06205719
Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam
- Conditions
- Interventions
- First Posted Date
- 2023-07-11
- Last Posted Date
- 2023-10-11
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Target Recruit Count
- 22
- Registration Number
- NCT05939674
- Locations
- 🇰🇷
Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnamdo, Korea, Republic of
Impact of Flumazenil on the Emergence Delirium
- First Posted Date
- 2023-01-12
- Last Posted Date
- 2023-09-06
- Lead Sponsor
- Korea University Guro Hospital
- Target Recruit Count
- 68
- Registration Number
- NCT05681377
- Locations
- 🇰🇷
Korea University Guro Hospital, Seoul, Korea, Republic of
Clinical Application Value of Remazolam Combined With Sugammadex Sodium in Anesthesia for Endotracheal Surgery Under Bronchoscopy
- First Posted Date
- 2022-07-21
- Last Posted Date
- 2022-10-26
- Lead Sponsor
- Zhejiang Cancer Hospital
- Target Recruit Count
- 34
- Registration Number
- NCT05468671
- Locations
- 🇨🇳
Zhejiang Cancer Hospital, Hanzhou, China
Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol
- Conditions
- Interventions
- First Posted Date
- 2022-06-28
- Last Posted Date
- 2023-01-13
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 66
- Registration Number
- NCT05435911
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea, Republic of
Comparison of Remimazolam With Flumazenil vs. Propofol During RFCA for Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2022-05-31
- Last Posted Date
- 2023-11-22
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 54
- Registration Number
- NCT05397886
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Reversal of Remimazolam by a Single Dose of Flumazenil
- Conditions
- Interventions
- First Posted Date
- 2022-05-19
- Last Posted Date
- 2023-05-19
- Lead Sponsor
- Konkuk University Medical Center
- Target Recruit Count
- 224
- Registration Number
- NCT05382806
- Locations
- 🇰🇷
Konkuk University Medical Center, Seoul, Seoul-T'ǔkpyǒlshi, Korea, Republic of
GABA Antagonist to Improve Reversal of Anesthesia With High-density EEG Surveillance
- First Posted Date
- 2020-04-01
- Last Posted Date
- 2020-04-01
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT04329585
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
🇨🇳National Taiwan University Cancer Center, Taipei, Taiwan
Drug Development Updates
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