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Acyclovir

Generic Name
Acyclovir
Brand Names
Sitavig, Xerese, Zovirax
Drug Type
Small Molecule
Chemical Formula
C8H11N5O3
CAS Number
59277-89-3
Unique Ingredient Identifier
X4HES1O11F

Overview

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Background

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Indication

An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients. An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older. An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis. An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.

Associated Conditions

  • Bell's Palsy
  • Chickenpox
  • Cytomegalovirus (CMV) Infections
  • Herpes Simplex Infections
  • Herpes Zoster
  • Herpes simplex encephalitis
  • Herpes simplex of the oral-labial
  • Herpes simplex type I reactivation
  • Recurrent Genital Herpes (RGH)
  • Recurrent Herpes Labialis
  • VZV re-activation
  • Acute Genital herpes
  • Acute Herpes labialis
  • Acute Herpetic keratitis
  • Severe Genital herpes

FDA Approved Products

Acyclovir
Manufacturer:Mylan Institutional Inc.
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2022/01/06
NDC:51079-550
Acyclovir
Manufacturer:RPK Pharmaceuticals, Inc.
Route:ORAL
Strength:800 mg in 1 1
Approved: 2021/04/06
NDC:53002-0270
Acyclovir
Manufacturer:Bryant Ranch Prepack
Route:ORAL
Strength:400 mg in 1 1
Approved: 2022/10/27
NDC:71335-2229
acyclovir
Manufacturer:RedPharm Drug, Inc.
Route:ORAL
Strength:200 mg in 1 1
Approved: 2023/02/15
NDC:67296-1495
Acyclovir
Manufacturer:A-S Medication Solutions
Route:ORAL
Strength:400 mg in 1 1
Approved: 2022/10/27
NDC:50090-0645

Singapore Approved Products

APO-ACYCLOVIR TABLET 200 mg
Manufacturer:APOTEX INC
Form:TABLET
Strength:200 mg
Online:Yes
Approved: 1998/10/05
Approval:SIN10154P
ZORAL 200 TABLET 200 mg
Manufacturer:PT ACTAVIS INDONESIA
Form:TABLET
Strength:200 mg
Online:Yes
Approved: 1996/04/16
Approval:SIN08639P
VILERM TABLET 800 mg
Manufacturer:SIAM BHEASACH CO LTD
Form:TABLET
Strength:800 mg
Online:Yes
Approved: 1997/04/16
Approval:SIN09297P
APO-ACYCLOVIR TABLET 800 mg
Manufacturer:APOTEX INC
Form:TABLET
Strength:800 mg
Online:Yes
Approved: 1998/10/23
Approval:SIN10310P
ZORAXIN SUSPENSION 200 mg/5 ml
Manufacturer:DUOPHARMA (M) SDN BHD
Form:SUSPENSION
Strength:200 mg/5 ml
Online:Yes
Approved: 1998/11/04
Approval:SIN10342P

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