Acyclovir

Generic Name: Acyclovir

Brand Names: Sitavig, Xerese, Zovirax

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁N_₅O_₃

CAS Number: 59277-89-3

Unique Ingredient Identifier: X4HES1O11F

Background: Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.

Acyclovir was granted FDA approval on 29 March 1982.

Indication: An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutan...

Associated Conditions: Bell's Palsy, Chickenpox, Cytomegalovirus (CMV) Infections, Herpes Simplex Infections, Herpes Zoster, Herpes simplex encephalitis, Herpes simplex of the oral-labial, Herpes simplex type I reactivation, Recurrent Genital Herpes (RGH), Recurrent Herpes Labialis, VZV re-activation, Acute Genital herpes, Acute Herpes labialis, Acute Herpetic keratitis, Severe Genital herpes

Associated Therapies: -

Clinical Trials

A Study to Compare the Efficacy and Safety of Valacyclovir Hydrochloride ( 256U87 ) Versus Acyclovir in the Treatment of Recurrent Anogenital Herpes Infections in HIV Infected Patients

Not Applicable

Completed

Conditions: Herpes Simplex
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Glaxo Wellcome

Registration Number: NCT00002000

Locations: 🇺🇸
Univ of South Alabama, Mobile, Alabama, United States
🇺🇸
West Haven Veterans Administration Med Ctr, West Haven, Connecticut, United States
🇺🇸
Univ of Mississippi Med Ctr, Jackson, Mississippi, United States

and more 19 locations

A Comparative Trial of Valacyclovir Hydrochloride ( 256U87 ) and Acyclovir for the Suppression of Anogenital Herpes Infections in HIV-Infected Patients

Not Applicable

Completed

Conditions: Herpes Simplex
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Glaxo Wellcome

Registration Number: NCT00002084

Locations: 🇺🇸
Univ TX Med Branch / Ctr for Clinical Studies, Nassau Bay, Texas, United States
🇺🇸
Thomas Audetta Clinic, Houston, Texas, United States
🇺🇸
Univ of Iowa Hosp & Clinic, Iowa City, Iowa, United States

and more 43 locations

The Safety and Effectiveness of Zidovudine Plus Acyclovir in Patients With Early HIV Infection

Not Applicable

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Glaxo Wellcome

Registration Number: NCT00002290

Locations: 🇺🇸
ViRx Inc, San Francisco, California, United States
🇺🇸
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸
Harper Hosp, Detroit, Michigan, United States

and more 11 locations

A Comparison of 882C87 Versus Acyclovir in the Treatment of Herpes Zoster in Patients With Weakened Immune Systems

Phase 3

Completed

Conditions: HIV Infections
Chickenpox

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Glaxo Wellcome

Target Recruit Count: 400

Registration Number: NCT00002315

Locations: 🇺🇸
Cedars Sinai Med Ctr, Los Angeles, California, United States
🇺🇸
N Texas Ctr for AIDS & Clin Rsch, Dallas, Texas, United States
🇺🇸
Univ TX Med Branch, Nassau Bay, Texas, United States

and more 22 locations

Double-Blind Placebo-Controlled Study Comparing the Combination of 15% SP-303 Gel With Acyclovir Versus Acyclovir Alone for the Treatment of Recurrent Herpes Simplex Virus (HSV) Infections in Subjects With Acquired Immunodeficiency Syndrome (AIDS)

Not Applicable

Completed

Conditions: Herpes Simplex
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2005-06-24

Lead Sponsor: Shaman Pharmaceuticals

Target Recruit Count: 400

Registration Number: NCT00002186

Locations: 🇺🇸
Johns Hopkins Univ / Division of Infectious Disease, Baltimore, Maryland, United States
🇺🇸
Division of Infectious Diseases / Univ of Texas - Houston, Houston, Texas, United States
🇺🇸
Gary Richmond MD, Fort Lauderdale, Florida, United States

and more 29 locations

A Study of Zidovudine Plus Acyclovir in HIV-Infected Patients

Phase 1

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2021-11-04

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 72

Registration Number: NCT00001010

Locations: 🇺🇸
Los Angeles County - USC Med Ctr, Los Angeles, California, United States
🇺🇸
Univ of California / San Diego Treatment Ctr, San Diego, California, United States
🇺🇸
Univ of Washington, Seattle, Washington, United States

A Study of Valacyclovir Hydrochloride in the Prevention of Life-Threatening Cytomegalovirus Disease in HIV-Infected Patients

Phase 3

Completed

Conditions: Cytomegalovirus Infections
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2011-03-01

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 1200

Registration Number: NCT00001038

Locations: 🇨🇦
Montreal Chest Institute, Montreal, Quebec, Canada
🇨🇦
Southern Alberta HIV Clinic / Foothills Hosp, Calgary, Alberta, Canada
🇺🇸
Yale Univ, New Haven, Connecticut, United States

and more 32 locations

A Multicenter, Double Blind, Comparative Study of Zidovudine Alone Versus Zidovudine and Acyclovir as Treatment for HIV-Infected Patients With CD4+ Counts Less Than 200 Cells/mm3

Phase 2

Completed

Conditions: HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2021-11-04

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 400

Registration Number: NCT00000712

Locations: 🇺🇸
Massachusetts General Hospital ACTG CRS, Worcester, Massachusetts, United States
🇺🇸
Regional Center for Infectious Disease, Wendover Medical Center CRS, Greensboro, North Carolina, United States
🇺🇸
Bmc Actg Crs, Boston, Massachusetts, United States

and more 5 locations

The Effect of Acyclovir Treatment of the Herpes Simplex Virus (HSV) Infection on HIV Levels in the Blood

Not Applicable

Completed

Conditions: Herpes Simplex
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2016-10-31

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 75

Registration Number: NCT00001115

Locations: 🇺🇸
Univ of Illinois Chicago / Howard Brown Hlth Ctr, Chicago, Illinois, United States
🇺🇸
Univ of Illinois - Chicago, Chicago, Illinois, United States
🇺🇸
Johns Hopkins Univ, Baltimore, Maryland, United States

and more 12 locations

Suppression of Cytomegalovirus Retinitis Utilizing High Dose Intravenous Acyclovir and Oral Zidovudine in Patients With AIDS

Not Applicable

Completed

Conditions: Cytomegalovirus Retinitis
HIV Infections

First Posted Date: 2001-08-31

Last Posted Date: 2021-11-02

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 25

Registration Number: NCT00000693

Locations: 🇺🇸
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸
Northwestern Univ Med School, Chicago, Illinois, United States

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