MedPath

Acyclovir

Generic Name
Acyclovir
Brand Names
Sitavig, Xerese, Zovirax
Drug Type
Small Molecule
Chemical Formula
C8H11N5O3
CAS Number
59277-89-3
Unique Ingredient Identifier
X4HES1O11F

Overview

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Background

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Indication

An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients. An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older. An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis. An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.

Associated Conditions

  • Bell's Palsy
  • Chickenpox
  • Cytomegalovirus (CMV) Infections
  • Herpes Simplex Infections
  • Herpes Zoster
  • Herpes simplex encephalitis
  • Herpes simplex of the oral-labial
  • Herpes simplex type I reactivation
  • Recurrent Genital Herpes (RGH)
  • Recurrent Herpes Labialis
  • VZV re-activation
  • Acute Genital herpes
  • Acute Herpes labialis
  • Acute Herpetic keratitis
  • Severe Genital herpes

FDA Approved Products

acyclovir
Manufacturer:Zydus Lifesciences Limited
Route:ORAL
Strength:800 mg in 1 1
Approved: 2023/10/24
NDC:65841-803
acyclovir
Manufacturer:Zydus Lifesciences Limited
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2022/11/05
NDC:70771-1371
ZOVIRAX
Manufacturer:Rebel Distributors Corp
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2006/03/01
NDC:42254-149
acyclovir
Manufacturer:Bryant Ranch Prepack
Route:ORAL
Strength:800 mg in 1 1
Approved: 2017/05/23
NDC:71335-1381
Acyclovir
Manufacturer:Camber Pharmaceuticals, Inc.
Route:ORAL
Strength:800 mg in 1 1
Approved: 2021/04/06
NDC:31722-778

Singapore Approved Products

ACYCLOVIR 800 STADA TABLET 800 mg
Manufacturer:STADA Arzneimittel AG
Form:TABLET
Strength:800 mg
Online:Yes
Approved: 1997/06/13
Approval:SIN09377P
ACYCLOVIR CREAM 5%
Manufacturer:PT INDOFARMA
Form:CREAM
Strength:5%
Online:Yes
Approved: 1998/02/12
Approval:SIN09628P
SALACLOVIR POWDER FOR SOLUTION FOR INFUSION 250MG/VIAL
Manufacturer:LABORATORIO REIG JOFRÉ, S.A
Form:INJECTION, POWDER, FOR SOLUTION
Strength:250 mg/ vial
Online:Yes
Approved: 2014/10/07
Approval:SIN14645P
VILERM TABLET 400 mg
Manufacturer:SIAM BHEASACH CO LTD
Form:TABLET
Strength:400 mg
Online:Yes
Approved: 1997/04/16
Approval:SIN09298P
AVORAX TABLET 200 mg
Manufacturer:XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
Form:TABLET
Strength:200 mg
Online:Yes
Approved: 1997/05/20
Approval:SIN09337P

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