MedPath

Acyclovir

Generic Name
Acyclovir
Brand Names
Sitavig, Xerese, Zovirax
Drug Type
Small Molecule
Chemical Formula
C8H11N5O3
CAS Number
59277-89-3
Unique Ingredient Identifier
X4HES1O11F

Overview

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Background

Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Acyclovir was granted FDA approval on 29 March 1982.

Indication

An acyclovir topical cream is indicated to treat recurrent herpes labialis in immunocompetent patients 12 years and older. Acyclovir oral tablets, capsules, and suspensions are indicated to treat herpes zoster, genital herpes, and chickenpox. An acyclovir topical ointment is indicated to treat initial genital herpes and limited non-life-threatening mucocutaneous herpes simplex in immunocompromised patients. An acyclovir cream with hydrocortisone is indicated to treat recurrent herpes labialis, and shortening lesion healing time in patients 6 years and older. An acyclovir buccal tablet is indicated for the treatment of recurrent herpes labialis. An acyclovir ophthalmic ointment is indicated to treat acute herpetic keratitis.

Associated Conditions

  • Bell's Palsy
  • Chickenpox
  • Cytomegalovirus (CMV) Infections
  • Herpes Simplex Infections
  • Herpes Zoster
  • Herpes simplex encephalitis
  • Herpes simplex of the oral-labial
  • Herpes simplex type I reactivation
  • Recurrent Genital Herpes (RGH)
  • Recurrent Herpes Labialis
  • VZV re-activation
  • Acute Genital herpes
  • Acute Herpes labialis
  • Acute Herpetic keratitis
  • Severe Genital herpes

FDA Approved Products

Acyclovir
Manufacturer:NuCare Pharmaceuticals,Inc.
Route:ORAL
Strength:200 mg in 1 1
Approved: 2022/01/20
NDC:68071-2235
ACYCLOVIR
Manufacturer:Direct RX
Route:ORAL
Strength:400 mg in 1 1
Approved: 2023/04/20
NDC:61919-370
acyclovir
Manufacturer:Zydus Lifesciences Limited
Route:ORAL
Strength:400 mg in 1 1
Approved: 2023/10/24
NDC:65841-802
Acyclovir
Manufacturer:H.J. Harkins Company, Inc.
Route:ORAL
Strength:200 mg in 1 1
Approved: 2011/10/27
NDC:52959-517
Acyclovir
Manufacturer:Zydus Lifesciences Limited
Route:TOPICAL
Strength:50 mg in 1 g
Approved: 2023/03/02
NDC:70771-1808

Singapore Approved Products

MEDOVIR 200 TABLET 200 mg
Manufacturer:MEDOCHEMIE LTD, MEDOCHEMIE (FAR EAST) LTD -ORAL FACILITY
Form:TABLET, FILM COATED
Strength:200 mg
Online:Yes
Approved: 1996/07/03
Approval:SIN08761P
ACYCLOVIR STADA CREAM 50 mg/g
Manufacturer:STADA Arzneimittel AG
Form:CREAM
Strength:50 mg/g
Online:Yes
Approved: 1997/06/13
Approval:SIN09380P
MEDOVIR 400 TABLET 400 mg
Manufacturer:MEDOCHEMIE LTD, MEDOCHEMIE (FAR EAST) LTD -ORAL FACILITY
Form:TABLET, FILM COATED
Strength:400 mg
Online:Yes
Approved: 1996/07/03
Approval:SIN08763P
ZORAL 400 TABLET 400 mg
Manufacturer:PT ACTAVIS INDONESIA
Form:TABLET
Strength:400 mg
Online:Yes
Approved: 1996/04/16
Approval:SIN08640P

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