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Hydroxyethyl Starch

Generic Name
Hydroxyethyl Starch
Brand Names
Hespan, Hextend, Volulyte, Voluven
Drug Type
Small Molecule
Chemical Formula
-
CAS Number
9005-27-0
Unique Ingredient Identifier
875Y4127EA
Background

Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.

HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.

Indication

An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.

Associated Conditions
Hypovolaemia
Associated Therapies
Granulocyte yield increase
Clinical Trials
Related News

Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension

Not Applicable
Completed
Conditions
Adverse Effect
Interventions
Drug: Crystalloid
Drug: Hydroxyethyl starch
First Posted Date
2022-07-27
Last Posted Date
2023-03-22
Lead Sponsor
General Hospital of Ningxia Medical University
Target Recruit Count
80
Registration Number
NCT05475990
Locations
🇨🇳

General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Days Alive and Out of Hospital for Patients With Sepsis

Completed
Conditions
Sepsis
Septic Shock
Interventions
Drug: Hydroxyethyl starch
Procedure: Early Goal Directed Therapy
Drug: Hydrocortisone
First Posted Date
2020-09-28
Last Posted Date
2024-02-23
Lead Sponsor
The George Institute for Global Health, Australia
Target Recruit Count
6213
Registration Number
NCT04567433
Locations
🇦🇺

Division of Critical Care, The George Institute for Global Health, Newtown, New South Wales, Australia

Different Preloads for Prevention of Hypotension in Patients Undergoing Elective CS Under Intrathecal Anesthesia

Early Phase 1
Conditions
Hypotension Drug-Induced
Interventions
Drug: Ringer
Drug: Voluven
First Posted Date
2018-03-15
Last Posted Date
2018-03-15
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT03465943

A Comparison of Eleview Versus Hetastarch as Injectate for EMR

Phase 4
Completed
Conditions
Delayed Bleeding
Procedural Bleeding
Post-Polypectomy Syndrome
Post Procedural Complication
Interventions
Drug: Eleview
Drug: Hetastarch
First Posted Date
2017-11-22
Last Posted Date
2019-12-17
Lead Sponsor
Indiana University
Target Recruit Count
160
Registration Number
NCT03350217
Locations
🇺🇸

Indiana University, Indianapolis, Indiana, United States

The Effects of Intravenous Fluids on Perfusion Index and Pleth Variability Index

Not Applicable
Completed
Conditions
Perfusion
Interventions
Drug: Ringer-Lactate Infusion Solution Bag
Drug: sodium chloride
Drug: Hydroxyethylstarch
First Posted Date
2017-02-09
Last Posted Date
2017-05-16
Lead Sponsor
Tokat Gaziosmanpasa University
Target Recruit Count
93
Registration Number
NCT03048162
Locations
🇹🇷

Gaziosmanpasa University, Tokat, Turkey

Endothelial Function After Cardiac Surgery

Not Applicable
Completed
Conditions
Endothelial Dysfunction
Interventions
Drug: Human albumin
Drug: Hydroxyethyl starch
First Posted Date
2016-08-29
Last Posted Date
2024-02-01
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
85
Registration Number
NCT02882074
Locations
🇺🇸

Cleveland Clinic, Cleveland, Ohio, United States

Volume Therapy With Crystalloids and Colloids and Hemodynamic Monitoring in Patients With Severe Sepsis

Phase 4
Withdrawn
Conditions
Severe Sepsis
Interventions
Drug: Volulyte
Drug: Jonosteril
First Posted Date
2015-10-27
Last Posted Date
2016-11-30
Lead Sponsor
Wuerzburg University Hospital
Registration Number
NCT02587078

HES and Acute Kidney Injury in Adult Cardiac Surgery

Completed
Conditions
Acute Kidney Injury After Adult Cardiac Surgery
Interventions
Drug: Crystalloid
Drug: HES
First Posted Date
2015-05-15
Last Posted Date
2015-10-30
Lead Sponsor
University of Liege
Target Recruit Count
697
Registration Number
NCT02445820

Evaluate the Nephrotoxicity by 6% Hydroxyethyl Starch 130/0.4 in Old Patients During Orthopaedic Surgery

Not Applicable
Completed
Conditions
Total Fluid Volume Increased
Interventions
Drug: Lactate Ringers
Drug: Hydroxyethyl Starch
First Posted Date
2015-02-12
Last Posted Date
2016-03-24
Lead Sponsor
Yuanyuan Zhang
Target Recruit Count
120
Registration Number
NCT02361736
Locations
🇨🇳

Tianjin Medical University General Hospital, Tianjin, Tianjin, China

Crystalloids or Colloids for Goal-directed Fluid Therapy With Closed-loop Assistance in Major Surgery

Phase 4
Completed
Conditions
Surgery
Interventions
Drug: Plasmalyte
Drug: Volulyte
First Posted Date
2014-12-09
Last Posted Date
2018-01-19
Lead Sponsor
Brugmann University Hospital
Target Recruit Count
160
Registration Number
NCT02312999
Locations
🇧🇪

CHU Brugmann, Brussels, Belgium

🇧🇪

Erasme, Brussels, Belgium

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