Tenofovir

Generic Name: Tenofovir

Brand Names: Vemlidy, Tenofovir disoproxil Zentiva

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₄N_₅O_₄P

CAS Number: 147127-20-6

Unique Ingredient Identifier: W4HFE001U5

Background: Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate. In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog. The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially available since 2008 in the form of tenofovir disoproxil and tenofovir alafenamide in order to obtain oral bioavailability.

Indication: Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.

To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, tenofovir alafenamide and tenofovir disoproxil.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Trial of Rectal Microbicide for HIV Prevention Begins in the United States

NIH launches trial to test safety and acceptability of a rectal microbicide douche containing tenofovir for HIV prevention among men who have sex with men. The study, HPTN 106, will compare the microbicide douche with oral PrEP over two two-month periods, assessing acceptability, adherence, and preference. The trial aims to expand HIV prevention options for at-risk populations.

Related Clinical Trials:

CROSSOVER STUDY OF ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR

avcr.cz

3 months ago

IOCB Prague expands overseas, opens a new branch in Boston

IOCB Prague launches a new lab in Boston, aiming to become an outpost for Czech science abroad, with a focus on medicinal chemistry and technology transfer. The branch, supported by private donations and IOCB revenues, plans to expand with additional research labs.

publicradiotulsa.org

3 months ago

'America's Nobel' goes to a power couple who made a startling discovery about HIV

Salim and Quarraisha Abdool-Karim won the Lasker Prize for their HIV research, focusing on heterosexual transmission and developing Tenofovir gel to prevent HIV in women. Their work contributed to reducing new HIV infections in South Africa.

aidsmap.com

2 years ago

DoxyPEP: Using antibiotics to prevent STIs

Doxycycline post-exposure prophylaxis (doxyPEP) effectively prevents syphilis and chlamydia in gay, bisexual men, and trans women, with less efficacy against gonorrhoea. Concerns about antibiotic resistance persist. Research supports its use in high-risk groups, though evidence for cisgender women is lacking. Guidelines vary, with some advocating for its use while others caution due to resistance risks.

Drug Development Updates

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