Tenofovir
- Generic Name
- Tenofovir
- Brand Names
- Vemlidy, Tenofovir disoproxil Zentiva
- Drug Type
- Small Molecule
- Chemical Formula
- C9H14N5O4P
- CAS Number
- 147127-20-6
- Unique Ingredient Identifier
- W4HFE001U5
- Background
Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate. In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog. The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially available since 2008 in the form of tenofovir disoproxil and tenofovir alafenamide in order to obtain oral bioavailability.
- Indication
Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.
To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, tenofovir alafenamide and tenofovir disoproxil.
- Associated Conditions
- -
- Associated Therapies
- -
Safety and Effectiveness of TFV 1% Gel, TDF Tablets, and FTC/TDF Tablets in Preventing HIV in Women
- Conditions
- HIV Infections
- Interventions
- Drug: Emtricitabine/tenofovir disoproxil fumarate placeboDrug: Emtricitabine/tenofovir disoproxil fumarateDrug: Tenofovir placeboDrug: Tenofovir 1% vaginal gelDrug: Tenofovir disoproxil fumarate placeboDrug: Tenofovir disoproxil fumarate
- First Posted Date
- 2008-06-26
- Last Posted Date
- 2021-10-29
- Target Recruit Count
- 5029
- Registration Number
- NCT00705679
- Locations
- 🇿🇼
Seke South CRS, Chitungwiza, Zimbabwe
🇿🇦CAPRISA Aurum CRS, Klerksdorp, South Africa
🇺🇬MU-JHU Research Collaboration CRS, Kampala, Uganda
Interventional Study of Mucosal and Antimicrobial Responses to Repeated Vaginal Applications of Tenofovir Gel in HIV Uninfected Women
- First Posted Date
- 2008-01-15
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 30
- Registration Number
- NCT00594373
- Locations
- 🇺🇸
Albert Einstein College of Medicine - East Campus GCRC (Herold) Non-Network CRS, Bronx, New York, United States
Adherence and Acceptability to and Blood Levels of Tenofovir Gel and Tablets in HIV Uninfected Women
- Conditions
- HIV Infections
- Interventions
- First Posted Date
- 2008-01-11
- Last Posted Date
- 2021-10-19
- Target Recruit Count
- 168
- Registration Number
- NCT00592124
- Locations
- 🇿🇦
Umkomaas CRS, Durban, KwaZulu-Natal, South Africa
🇺🇸Alabama Microbicide CRS, Birmingham, Alabama, United States
🇿🇦Botha's Hill CRS, Durban, KwaZulu-Natal, South Africa
Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery
- First Posted Date
- 2007-10-08
- Last Posted Date
- 2021-10-25
- Target Recruit Count
- 21
- Registration Number
- NCT00540605
- Locations
- 🇺🇸
Pitt CRS, Pittsburgh, Pennsylvania, United States
Safety and Effectiveness of Short-Term Anti-HIV Drug Therapy for Recent HIV-1 Infection
- Conditions
- HIV Infections
- Interventions
- Drug: Tenofovir disoproxil fumarate/EmtricitabineDrug: Lopinavir/Ritonavir
- First Posted Date
- 2006-12-21
- Last Posted Date
- 2013-02-20
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 16
- Registration Number
- NCT00414518
- Locations
- 🇿🇼
University of Zimbabwe College of Health Sciences, Harare, Zimbabwe
🇺🇸AIDS Research Consortium of Atlanta, Atlanta, Georgia, United States
🇺🇸University of Colorado Health Sciences Center, Denver, Colorado, United States
Safety and Acceptability of a Vaginal Microbicide
- Conditions
- HIV InfectionsHepatitis B, Chronic
- First Posted Date
- 2005-05-27
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 200
- Registration Number
- NCT00111943
- Locations
- 🇺🇸
Bronx- Lebanon Hospital Center Clinical Research Site (BLHC CRS), Bronx, New York, United States
🇺🇸Alabama Microbicide CRS, Birmingham, Alabama, United States
🇮🇳NARI Arogya Aadhar Clinic CRS, Pune, Maharashtra, India
Daily Tenofovir DF to Prevent HIV Infection Among Sex Workers in Cambodia
- Conditions
- HIV InfectionsHIV Seronegativity
- Locations
- 🇰ðŸ‡
NCAHDS, Phnom Penh, Cambodia
Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
- Conditions
- HIV Infections
- Interventions
- Drug: darunavir/ritonavir dosage #1Drug: TAF w/cobicistatDrug: TAF w/cobicistat or ritonavirDrug: tenofovir alafenamide fumarate (TAF)Drug: elvitegravir/cobicistatDrug: darunavir/cobicistatDrug: atazanavir/cobicistatDrug: lopinavir/ritonavir dosage #1Drug: atazanavir/ritonavir/tenofovir dosage #1Drug: lopinavir/ritonavir dosage #2Drug: indinavir/ritonavir dosage #1Drug: fosamprenavir/ritonavirDrug: atazanavir/ritonavir dosage #1Drug: didanosine delayed release (Videx® EC)Drug: emtricitabineDrug: nelfinavir dosage #1Drug: tipranavir/ritonavirDrug: etravirineDrug: darunavir/ritonavir dosage #4Drug: indinavir/ritonavir dosage #2Drug: rilpivirineDrug: ethambutolDrug: efavirenzDrug: raltegravirDrug: dolutegravirDrug: kanamycinDrug: nevirapineDrug: amprenavirDrug: abacavirDrug: tenofovirDrug: maravirocDrug: nelfinavir dosage #2Drug: darunavir/ritonavir dosage #2Drug: lopinavir/ritonavir dosage #3Drug: lopinavir/ritonavir dosage #4Drug: tenofovir/atazanavir/ritonavir dosage #2Drug: atazanavir/ritonavir dosage #2Drug: rifampicinDrug: amikacinDrug: etonogestrel implantDrug: darunavir/ritonavir dosage #3Drug: capreomycinDrug: ethinyl estradiolDrug: isoniazidDrug: moxifloxacinDrug: levoflaxacinDrug: pyrazinamideDrug: ofloxacinDrug: ethionamide/prothionamideDrug: terizidone/cycloserineDrug: para-aminosalicylic acid (PAS)Drug: high dose INHDrug: bedaquilineDrug: clofazamineDrug: delamanidDrug: linezolidDrug: pretomanid
- First Posted Date
- 2002-08-01
- Last Posted Date
- 2022-07-22
- Target Recruit Count
- 1578
- Registration Number
- NCT00042289
- Locations
- 🇺🇸
Usc La Nichd Crs, Los Angeles, California, United States
🇿🇦Wits RHI Shandukani Research Centre CRS, Johannesburg, Gauteng, South Africa
🇺🇸Boston Medical Center Ped. HIV Program NICHD CRS, Boston, Massachusetts, United States
A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
- Conditions
- HIV Infections
- First Posted Date
- 2002-05-13
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 402
- Registration Number
- NCT00036452
- Locations
- 🇺🇸
The Ohio State Univ. AIDS CRS, Columbus, Ohio, United States
🇺🇸MetroHealth CRS, Cleveland, Ohio, United States
🇺🇸Pitt CRS, Pittsburgh, Pennsylvania, United States
Safety and Acceptability of the Anti-Microbe Vaginal Gel, PMPA Gel
- Conditions
- HIV Infections
- First Posted Date
- 2001-12-14
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 120
- Registration Number
- NCT00028132
- Locations
- 🇺🇸
3535 Market Street CRS, Philadelphia, Pennsylvania, United States
🇺🇸Bronx- Lebanon Hospital Center Clinical Research Site (BLHC CRS), Bronx, New York, United States
🇺🇸The Miriam Hosp., Div. of Infectious Disease, Providence, Rhode Island, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.