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D-alpha-Tocopherol acetate

Generic Name
D-alpha-Tocopherol acetate
Drug Type
Small Molecule
Chemical Formula
C31H52O3
CAS Number
58-95-7
Unique Ingredient Identifier
A7E6112E4N

Overview

Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is considered the natural formation of alpha-tocopherol and generally exhibits the greatest bioavailability out of all of the alpha-tocopherol stereoisomers. Moreover, RRR-alpha-tocopherol acetate is a relatively stabilized form of vitamin E that is most commonly used as a food additive when needed . Alpha-tocopherol acetate is subsequently most commonly indicated for dietary supplementation in individuals who may demonstrate a genuine deficiency in vitamin E. Vitamin E itself is naturally found in various foods, added to others, or used in commercially available products as a dietary supplement. The recommended dietary allowances (RDAs) for vitamin E alpha-tocopherol are: males = 4 mg (6 IU) females = 4 mg (6 IU) in ages 0-6 months, males = 5 mg (7.5 IU) females = 5 mg (7.5 IU) in ages 7-12 months, males = 6 mg (9 IU) females = 6 mg (9 IU) in ages 1-3 years, males = 7 mg (10.4 IU) females = 7 mg (10.4 IU) in ages 4-8 years, males = 11 mg (16.4 IU) females = 11 mg (16.4 IU) in ages 9-13 years, males = 15 mg (22.4 IU) females = 15 mg (22.4 IU) pregnancy = 15 mg (22.4 IU) lactation = 19 mg (28.4 IU) in ages 14+ years . Most individuals obtain adequate vitamin E intake from their diets; genuine vitamin E deficiency is considered to be rare. Nevertheless, vitamin E is known to be a fat-soluble antioxidant that has the capability to neutralize endogenous free radicals. This biologic action of vitamin E consequently continues to generate ongoing interest and study in whether or not its antioxidant abilities may be used to help assist in preventing or treating a number of different conditions like cardiovascular disease, ocular conditions, diabetes, cancer and more. At the moment however, there exists a lack of formal data and evidence to support any such additional indications for vitamin E use.

Indication

In addition to any following information, owing to d-alpha-Tocopherol acetate's closely related chemical nature with alpha-Tocopherol acetate, please also refer to the drug information page for alpha-Tocopherol acetate for further data. Vitamin E, known for its antioxidant activities, is protective against cardiovascular disease and some forms of cancer and has also demonstrated immune-enhancing effects. It may be of limited benefit in some with asthma and rheumatoid arthritis. It may be helpful in some neurological diseases including Alzheimer's, some eye disorders including cataracts, and diabetes and premenstrual syndrome. It may also help protect skin from ultraviolet irradiation although claims that it reverses skin aging, enhances male fertility and exercise performance are poorly supported. It may help relieve some muscle cramps.

Associated Conditions

No associated conditions information available.

Clinical Trials

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Posted
Study ID
Phase
Status
Sponsor

No clinical trials found

No clinical trials found for this drug

FDA Drug Approvals

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Manufacturer
NDC Code
Route
Strength
Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

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Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

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Manufacturer
Approval Number
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Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

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Company
Approval Number
Drug Type
Dosage Form
Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product
Registration No.
Company
Licence No.
Strength
Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product
ARTG ID
Sponsor
Registration Type
Status
Registration Date
S.O.H Superior Omega 3 High Potency
280858
Medicine
A
9/29/2016
Kids Multi
329564
Medicine
A
2/6/2020
PREMEO
172667
Medicine
A
6/29/2010
Bio Solution DHA Growth
323160
Medicine
A
9/13/2019
BLACKMORES ULTIMATE RADIANT SKIN
364753
Medicine
A
5/6/2021
Nature's Family Premium Vitamax
314002
Nature's Family Australia Pty Ltd
Medicine
A
2/7/2019
UltraClean EPA/DHA Plus
309331
Medicine
A
9/17/2018
InNatal
346421
Medicine
A
10/22/2020
Chemists' Own PROVANCE Clean EPA/DHA
370293
Medicine
A
6/28/2021
GO Royal Jelly + Vitamin E
445391
Medicine
A
4/5/2024

Health Canada Drug Approvals

Approved Product
Company
DIN
Dosage Form
Strength
Market Date
C.E.B12 COMPLEX PWR
pure life international prods inc.
02051117
Powder - Oral
6 UNIT / G
12/31/1993
VITAMINS E, C & BETA CAROTENE WITH SELENIUM
hillestad pharmaceuticals usa
02202034
Wafer - Oral
180 MG / UNIT
11/1/1995
GRAND MASTER FORMULA TAB
nutrition for life international
02053349
Tablet - Oral
66.67 UNIT
12/30/1996
EFAMOL CALCIUM - CAP
efamol research inc.
02163993
Capsule - Oral
13.6 UNIT
7/30/1996
IRON, VIT & MIN SUPP
avacare, division of jeunique international inc.
00631426
Tablet - Oral
10 UNIT / TAB
12/31/1985
VITAMIN E CAP 200UNIT
shoppers drug mart inc.
00414956
Capsule - Oral
200 UNIT / CAP
12/31/1977
NUTROL V CAPSULE
rolmex international inc.
02025663
Capsule - Oral
50 UNIT
12/31/1994
VITAMIN E 400I.U.WITH SELENIUM 50MCG-TAB
health-wise nutrition inc.
02167999
Tablet - Oral
400 UNIT
8/15/1997
ONE A DAY ADVANCE - ADULTS 50 + - TABS
bayer inc consumer care
02155206
Tablet - Oral
60 UNIT
12/31/1996
PRIMANOL-BORAGE W.BETA-CAR.AND VIT.C AND E
jamieson laboratories ltd
02050498
Tablet - Oral
15 UNIT / TAB
12/31/1993

CIMA AEMPS Drug Approvals

Approved Product
Company
Registration Number
Pharmaceutical Form
Prescription Type
Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product
Company
License Number
Dosage Form
Strength
Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

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Company
License Number
Dosage Form
Strength
Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product
Company
Registration Number
Dosage Form
Strength
Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name
MA Holder
MA Number
Pharmaceutical Form
Active Ingredient
Authorization Date
No UK EMC drug information found for this drug.

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