Overview
The ZYCOV-D vaccine candidate was developed by Cadila Healthcare Ltd. based in India. The vaccine was developed using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of interest. Once the plasmid DNA is introduced into host cells and the viral protein is translated, it elicits a strong immune response, stimulating the humoral and cellular components of the immune system. The DNA vaccine platform offers minimal biosafety requirements, more improved vaccine stability, and lower cold chain requirements. Phase I clinical trials of this vaccine candidate were completed in July 2020, with the company reporting successful dosing and tolerance. As of August, 2020 the candidate is in Phase II clinical trials.
Background
The ZYCOV-D vaccine candidate was developed by Cadila Healthcare Ltd. based in India. The vaccine was developed using a DNA vaccine platform with a non-replicating and non-integrating plasmid carrying the gene of interest. Once the plasmid DNA is introduced into host cells and the viral protein is translated, it elicits a strong immune response, stimulating the humoral and cellular components of the immune system. The DNA vaccine platform offers minimal biosafety requirements, more improved vaccine stability, and lower cold chain requirements. Phase I clinical trials of this vaccine candidate were completed in July 2020, with the company reporting successful dosing and tolerance. As of August, 2020 the candidate is in Phase II clinical trials.
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
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No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
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| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||