醋羟胺酸 (Lithostat)

概览

Acetohydroxamic acid is a synthetic urea derivative used to treat urea splitting bacterial infections of the urinary tract.

作用机制

Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.

适应症

Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.

• Chronic urea-splitting urinary infection