Gadoteric acid
- Generic Name
- Gadoteric acid
- Brand Names
- Dotarem
- Drug Type
- Small Molecule
- Chemical Formula
- C16H25GdN4O8
- CAS Number
- 72573-82-1
- Unique Ingredient Identifier
- QVF9Y6955W
- Background
Gadoteric acid is a macrocycle-structured gadolinium-based MRI contrast agent. It is composed of the organic acid DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) used for its chelating properties, and gadolinium (Gd3+). As a paramagnetic molecule, gadoterate develops a magnetic moment when placed in a magnetic field. This magnetic moment enha...
- Indication
Gadoteric acid is indicated for intravenous use with magnetic resonance imaging (MRI) in brain (intracranial), spine and associated tissues in adult and pediatric patients (2 years of age and older) to detect and visualize areas with disruption of the blood brain barrier (BBB) and/or abnormal vascularity.
- Associated Conditions
- -
- Associated Therapies
- -
Mangafodipir - an Intracellular Contrast Agent for Magnetic Resonance Imaging (MRI): Measuring Manganese Uptake Rate in Heart Failure Patients With Preserved Ejection Fraction (HFpEF) Patients.
- Conditions
- Interventions
- First Posted Date
- 2024-12-12
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- IC TARGETS AS
- Target Recruit Count
- 42
- Registration Number
- NCT06731738
- Locations
- 🇳🇴
Oslo University Hospital, Department of Cardiology, Rikshospitalet Sognsvannsveien 20, Oslo, Norway
Performance of Elucirem® in DSC-MRI Perfusion of Brain Gliomas
- Conditions
- Interventions
- First Posted Date
- 2023-09-28
- Last Posted Date
- 2024-05-03
- Lead Sponsor
- Guerbet
- Target Recruit Count
- 138
- Registration Number
- NCT06057168
- Locations
- 🇮🇹
Policlinico Universitario Agostino Gemelli, Roma, Italy
🇵🇱Szpital Specjalistyczny im.L.Rydygiera, Kraków, Poland
🇮🇹Ospedale Papa Giovanni XXIII, Bergamo, Italy
Collagen-targeted PET Imaging for Early Interstitial Lung Disease
- First Posted Date
- 2022-06-14
- Last Posted Date
- 2024-07-30
- Lead Sponsor
- Massachusetts General Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT05417776
- Locations
- 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States
Gadolinium-Based-Contrast-Agents (GBCA) Enhancement During MR Urography
- Conditions
- Interventions
- First Posted Date
- 2019-04-10
- Last Posted Date
- 2019-04-10
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 500
- Registration Number
- NCT03910114
- Locations
- 🇺🇸
Vanderbilt Childeen's Hospital, Nashville, Tennessee, United States
🇺🇸Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Intra-individual Open-label, Single Center Study to Compare Unenhanced MRI With Dotarem Enhanced MRI
- First Posted Date
- 2017-01-18
- Last Posted Date
- 2022-05-20
- Lead Sponsor
- Phoenix Children's Hospital
- Target Recruit Count
- 250
- Registration Number
- NCT03023566
- Locations
- 🇺🇸
Phoenix Children's Hospital, Phoenix, Arizona, United States
Assessment of Immediate Adverse Reactions From Dotarem in Children Under 2 Years of Age
- Conditions
- First Posted Date
- 2015-11-20
- Last Posted Date
- 2019-09-13
- Lead Sponsor
- St. Louis University
- Target Recruit Count
- 150
- Registration Number
- NCT02609919
- Locations
- 🇺🇸
Saint Louis University, Saint Louis, Missouri, United States
Evaluation of Inner Ear and Brain Structures With Contrast-enhanced MRI in Healthy Subjects (HYDROPS)
- First Posted Date
- 2015-08-20
- Last Posted Date
- 2020-11-18
- Lead Sponsor
- University Hospital, Grenoble
- Target Recruit Count
- 25
- Registration Number
- NCT02529475
- Locations
- 🇫🇷
GrenobleUniversityHospital, Grenoble, France
🇫🇷Hôpital Charles Nicolle, Rouen, France
🇫🇷Hôpital Lariboisière, Paris, France
DOTAREM Pharmacokinetics and Safety Study in Pediatric Subjects Aged < 2 Years
- First Posted Date
- 2015-04-08
- Last Posted Date
- 2017-03-09
- Lead Sponsor
- Guerbet
- Target Recruit Count
- 51
- Registration Number
- NCT02411201
- Locations
- 🇫🇷
CHU, Bordeaux, France
🇵🇱Uniwersytecki Szpital Dziecięcy w Lublinie, Lublin, Poland
🇫🇷Hôpital de Hautepierre, Strasbourg, France
Evaluation of Gadoterate in Patients With Decreased Kidney Function
- First Posted Date
- 2015-03-06
- Last Posted Date
- 2019-06-07
- Lead Sponsor
- Loyola University
- Target Recruit Count
- 46
- Registration Number
- NCT02382380
- Locations
- 🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States
Validation of New Markers of Glomerular Filtration Rate: Dota Gadolinium and Calcium EDTA (MultiGFR)
- Conditions
- Interventions
- First Posted Date
- 2014-11-07
- Last Posted Date
- 2018-05-18
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 166
- Registration Number
- NCT02286258
- Locations
- 🇫🇷
Hopital Europeen Georges Pompidou (centre d'investigations cliniques), Paris, France
🇫🇷Hopital Europeen Georges Pompidou (Service de Nephrologie), Paris, France
🇫🇷Hopital Europeen Georges Pompidou (service de Physiologie et des Radioisotopes), Paris, France
Drug Development Updates
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