Lecanemab

Generic Name: Lecanemab

Brand Names: Leqembi

Drug Type: Biotech

Chemical Formula: -

CAS Number: 1260393-98-3

Unique Ingredient Identifier: 12PYH0FTU9

Background: Lecanemab is a recombinant humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble and insoluble forms of amyloid beta (Aβ), which are implicated in the pathophysiology of Alzheimer’s disease. Lecanemab works to reduce Aβ plaques and prevent Aβ deposition in the brain with high selectivity to Aβ protofibrils. In clini...

Indication: Lecanemab is indicated for the treatment of Alzheimer’s disease. Treatment with lecanemab should be initiated in patients with mild cognitive impairment or mild dementia stage of disease, the population in which treatment was initiated in clinical trials.

Associated Conditions: Alzheimer's Disease (AD)

Associated Therapies: -

Clinical Trials

Alzheimer's drug Leqembi promises to give patients more time, but they face a long road to treatment

Leqembi, an Alzheimer's drug from Biogen and Eisai, offers early-stage patients more independent living time but faces hurdles like reimbursement issues, diagnostic tests, and neurologist availability. Missie Meeks, an early recipient, reports improved daily functioning. Despite risks like brain swelling and bleeding, some patients find the process worth it for extended normal life.

cnbc.com

3 months ago

Leqembi could give Alzheimer's patients more time, but road to treatment is long

Leqembi, an Alzheimer's drug from Biogen and Eisai, promises to extend patients' normal, independent lives, though it's not a cure. Missie Meeks, diagnosed with early Alzheimer's, benefits from Leqembi, which moderately slows cognitive decline. However, the drug's rollout faces challenges like insurance hurdles and limited neurologist availability. Despite risks of brain swelling and bleeding, some patients find the process worth it for extended quality time with loved ones.

Drug Development Updates

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