Nicotinamide
- Generic Name
- Nicotinamide
- Brand Names
- Alertonic, Fortaplex, Infuvite, Infuvite Pediatric, Mvc-fluoride, Mvi Pediatric, Natafort, Neo-bex, Nicomide, Pregvit, Tandem Plus
- Drug Type
- Small Molecule
- Chemical Formula
- C6H6N2O
- CAS Number
- 98-92-0
- Unique Ingredient Identifier
- 25X51I8RD4
- Background
An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
- Indication
用于防治糙皮病等烟酸缺乏病，也用于防治心脏传导阻滞。
- Associated Conditions
- Gastrointestinal insufficiency, Hepatic Insufficiency, Macrocytic anemia, Secondary anemia, Vitamin Deficiency, Severe debilitation
- Associated Therapies
- Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation
Novel Compounds NR and CoQ10 Show Promise in Improving Metabolism and Reducing Inflammation in CKD Patients
• UC Davis Health researchers demonstrate that nicotinamide riboside and coenzyme Q10 supplementation reduces oxidative stress markers and improves metabolic function in chronic kidney disease patients.
• The randomized placebo-controlled trial revealed CoQ10 significantly decreased inflammatory markers IL-13 and CRP, while enhancing lipid metabolism and stress response gene expression.
• Both compounds showed promising safety profiles and metabolic benefits, suggesting potential therapeutic applications beyond kidney disease treatment.
Psilocybin-Assisted Therapy Shows Promise for Mental Health in Cancer Patients and Alcohol Use Disorder
• Psilocybin-assisted psychotherapy significantly reduced anxiety, depression, and other psychological distress in cancer patients, with benefits lasting up to six months.
• In patients with alcohol use disorder, psilocybin therapy led to reduced impulsivity, depression, and increased openness to emotions, observed seven months post-treatment.
• Studies highlight the potential of psilocybin, when administered under medical supervision and combined with psychotherapy, to induce lasting, positive personality changes.
• Researchers plan to explore the efficacy of psilocybin-assisted psychotherapy for opioid-use disorder, building on observed benefits in alcohol use disorder and cancer patients.
Vitamin B3 Shows Promise in Reducing Lung Inflammation in COPD Patients
• A recent study reveals that daily intake of vitamin B3 significantly reduces lung inflammation in individuals with Chronic Obstructive Pulmonary Disease (COPD).
• The research demonstrated a notable decrease in interleukin 8 (IL-8), a key marker of inflammation, by 53% after six weeks and 63% after 18 weeks.
• Vitamin B3 treatment also increased levels of NAD, a chemical that declines with age and DNA damage, suggesting potential benefits against cellular aging.
• Researchers plan further studies to validate these findings and explore the long-term efficacy of nicotinamide riboside as a COPD treatment.
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.
© Copyright 2025. All Rights Reserved by MedPath