Overview
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat. It is used to treat hypertension and heart failure. ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with hydrochlorothiazide was also approved on 28 December 1999.
Indication
Quinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure. Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.
Associated Conditions
- Congestive Heart Failure (CHF)
- Diabetic Nephropathy
- Hypertension
- Left Ventricular Dysfunction
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/02/06 | Phase 4 | Completed | |||
2017/01/26 | Phase 4 | Completed | |||
2009/06/30 | N/A | Completed | |||
2008/11/21 | Not Applicable | Completed | |||
2008/04/02 | Phase 4 | Completed | |||
2008/04/01 | Phase 1 | Completed | |||
2008/04/01 | Phase 1 | Completed | |||
2008/04/01 | Phase 1 | Completed | |||
2008/04/01 | Phase 1 | Completed | |||
2006/04/12 | Phase 4 | Terminated | Montreal Heart Institute |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Carilion Materials Management | 68151-1021 | ORAL | 10 mg in 1 1 | 6/13/2014 | |
| Carilion Materials Management | 68151-1020 | ORAL | 5 mg in 1 1 | 6/13/2014 | |
| Carilion Materials Management | 68151-1022 | ORAL | 20 mg in 1 1 | 6/13/2014 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Quinapril Hydrochloride Tablets | 国药准字H19990330 | 化学药品 | 片剂(薄膜衣) | 6/29/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
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