Quinapril
- Generic Name
- Quinapril
- Brand Names
- Accupril, Accuretic
- Drug Type
- Small Molecule
- Chemical Formula
- C25H30N2O5
- CAS Number
- 85441-61-8
- Unique Ingredient Identifier
- RJ84Y44811
Overview
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat. It is used to treat hypertension and heart failure. ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with hydrochlorothiazide was also approved on 28 December 1999.
Background
Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat. It is used to treat hypertension and heart failure. ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers. Quinapril was granted FDA approval on 19 November 1991. A combination tablet with hydrochlorothiazide was also approved on 28 December 1999.
Indication
Quinapril is indicated for the treatment of hypertension and as an adjunct therapy in the treatment of heart failure. Quinapril in combination with hydrochlorothiazide is indicated for the treatment of hypertension.
Associated Conditions
- Congestive Heart Failure (CHF)
- Diabetic Nephropathy
- Hypertension
- Left Ventricular Dysfunction
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2005/12/23 | Phase 4 | Completed | Montreal Heart Institute | ||
2005/09/08 | Phase 4 | Completed | |||
2005/09/07 | Phase 4 | Completed |
FDA Approved Products
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