Succinylcholine

Overview

Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter acetylcholine (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short medical procedures requiring brief periods of muscle relaxation.

Indication

Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Muscle Relaxant Effect and Safety of Mivacurium Chloride and Succinylcholine for Bronchoscopy	2024/11/29	NCT06709066	Not Applicable	Not yet recruiting	Peng Liang
Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine	2023/09/08	NCT06029049	Phase 4	Recruiting	The University of Texas Health Science Center, Houston
High-Resolution Solid-State Manometry of the Effect of Succinylcholine on Barrier Pressure	2022/09/27	NCT05556408	Phase 4	Completed	China-Japan Friendship Hospital
Intubating Conditions During Rapid Sequence Induction in Elderly With Either Suxamethonium 1.0 mg/kg or Rocuronium 1.0 mg/kg	2021/05/03	NCT04868409	Phase 4	Completed	Matias Vested
The Effect of Pretreatment With Roc on Succinylcholine Myalgias	2020/10/09	NCT04581395	Phase 3	Completed	Indiana University
Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)	2018/05/22	NCT03532178	Phase 2	Completed	University of California, San Francisco
Effects of Succinylcholine on Nonintubated Thoracoscopic Surgery	2018/03/19	NCT03469323	Not Applicable	UNKNOWN	National Taiwan University Hospital
Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals	2016/09/26	NCT02914119	N/A	Completed	Jakob Louis Thomsen
General Anesthesia Versus Sedation During Intra-arterial Treatment for Stroke	2016/07/04	NCT02822144	Phase 3	Completed	Rennes University Hospital
Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery	2016/02/05	NCT02676011	Phase 2	Completed	Assiut University

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Succinylcholine Chloride	Hikma Pharmaceuticals USA Inc.	0143-9338	INTRAMUSCULAR, INTRAVENOUS	20 mg in 1 mL	6/26/2023
Succinylcholine Chloride	Hikma Pharmaceuticals USA Inc.	0641-6234	INTRAMUSCULAR, INTRAVENOUS	20 mg in 1 mL	1/2/2024

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
ETHICHOLINE INJECTION 100 mg/2 ml	Siegfried Hameln GmbH	SIN05861P	INJECTION	103 mg/2mL	5/13/1991
MARTINDALE PHARMA SUXAMETHONIUM CHLORIDE SOLUTION FOR INJECTION 50MG/ML	MACARTHYS LABORATORIES LTD T\A MARTINDALE PHARMA	SIN15643P	INJECTION, SOLUTION	50MG/ML	3/8/2019

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SUXAMETHONIUM MEDSURGE suxamethonium chloride dihydrate 100 mg/2 mL solution for injection vial	438912	Medsurge Pharma Pty Ltd	Medicine	A	10/2/2024
SUXAMETHONIUM INTAS suxamethonium chloride dihydrate 100 mg/2 mL solution for injection pre-filled syringe	330020	Accord Healthcare Pty Ltd	Medicine	A	8/26/2021
SUXAMETHONIUM ACCORD suxamethonium chloride dihydrate 100 mg/2 mL solution for injection pre-filled syringe	330024	Accord Healthcare Pty Ltd	Medicine	A	8/26/2021
SUXAMETHONIUM JUNO suxamethonium chloride dihydrate 100 mg/2 mL injection ampoule	320687	Juno Pharmaceuticals Pty Ltd	Medicine	A	1/17/2020
SUXAMETHONIUM MEDICIANZ suxamethonium chloride dihydrate 100 mg/2 mL solution for injection vial	438911	Medsurge Pharma Pty Ltd	Medicine	A	10/2/2024

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
No Health Canada approvals found for this drug.

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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