Overview
Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamines, such as diphenhydramine, which readily bind to off-targets that contribute to side effects such as sedation. Fexofenadine is the major active metabolite of terfenadine and is administered as a racemic mixture in which both enantiomers display approximately equivalent antihistamine activity.
Indication
In the United States, fexofenadine is indicated for the symptomatic treatment of allergic rhinitis in patients ≥2 years old and chronic idiopathic urticaria in patients ≥6 months old. In Canada, fexofenadine carries the same indications but is approved only for patients ≥12 years old. Fexofenadine is also available in combination with pseudoephedrine for the symptomatic treatment of season allergic rhinitis in patients ≥12 years old.
Associated Conditions
- Allergic Rhinitis (AR)
- Chronic Idiopathic Urticaria
- Seasonal Allergic Rhinitis
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2012/02/03 | Not Applicable | Completed | |||
2011/11/10 | Phase 4 | Completed | |||
2011/03/02 | Phase 3 | Completed | |||
2010/10/26 | Phase 3 | Completed | |||
2010/07/29 | Phase 2 | Completed | The Connecticut Sinus Center, PC | ||
2010/05/28 | Phase 1 | Completed | |||
2010/05/28 | Phase 1 | Completed | |||
2010/02/10 | Phase 1 | Completed | |||
2010/02/10 | Phase 1 | Completed | |||
2009/12/16 | Phase 2 | Completed |
FDA Drug Approvals
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| No FDA approvals found for this drug. | |||||
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HSA Drug Approvals
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NMPA Drug Approvals
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PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
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