Overview
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors . It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.
Background
Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors . It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.
Indication
可用于各种原因所致的炎症、水肿、血肿、血栓症如支气管炎、支气管哮喘、急性肺炎、产后乳房充血、乳腺炎、产后血栓性静脉炎、视网膜炎等,与抗菌药物合用治疗关节炎、关节周围炎、蜂窝织炎、小腿溃疡等均有效。眼科用于治疗视网膜炎。
Associated Conditions
- Swelling
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2024/07/17 | Phase 1 | Recruiting | Krishnadevaraya College of Dental Sciences & Hospital | ||
2022/02/28 | Phase 1 | UNKNOWN | |||
2020/08/13 | Phase 2 | Completed | |||
2019/06/06 | Phase 2 | UNKNOWN |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
---|---|---|---|---|---|
No FDA approvals found for this drug. |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
---|---|---|---|
No EMA approvals found for this drug. |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
---|---|---|---|---|---|
No HSA approvals found for this drug. |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
---|---|---|---|---|---|
Bromelain Enteric-coated Tablets | 国药准字H20033908 | 化学药品 | 片剂(肠溶片) | 8/21/2020 | |
Bromelain Enteric-coated Tablets | 国药准字H20003383 | 化学药品 | 片剂 | 6/19/2020 | |
Bromelain Enteric-coated Tablets | 国药准字H20003084 | 化学药品 | 片剂(肠溶片) | 8/21/2020 | |
Bromelain Enteric-coated Tablets | 国药准字H20003382 | 化学药品 | 片剂 | 3/13/2020 | |
Bromelain Enteric-coated Tablets | 国药准字H45021409 | 化学药品 | 片剂 | 8/16/2020 | |
Bromelain Enteric-coated Tablets | 国药准字H20003785 | 化学药品 | 片剂 | 7/14/2020 | |
Bromelains Enteric-coated Capsules | 国药准字H45021171 | 化学药品 | 胶囊剂 | 8/16/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
---|---|---|---|---|---|
No PPB approvals found for this drug. |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
---|---|---|---|---|---|
Ultra Inflamase | 351743 | Medicine | A | 12/15/2020 | |
Gut Calm + Restore | 444372 | Medicine | A | 3/25/2024 | |
Plexus ProBioFit | 353839 | Medicine | A | 1/29/2021 | |
ProBioFit | 483565 | Medicine | A | 3/21/2025 | |
Eagle Clinical Tresos B Professional + | 489429 | Medicine | A | 5/21/2025 | |
Eagle Vegie Digestaid | 330721 | Medicine | A | 3/4/2020 | |
Lymphodran Plus | 302620 | Medicine | A | 5/4/2018 | |
Bioglan Platinum Digest Eze | 423692 | Medicine | A | 10/3/2023 | |
Inner Essentials Skin + Gut Renew | 375454 | Medicine | A | 9/29/2021 | |
BioFlam | 217896 | Medicine | A | 11/29/2013 |