MedPath

Bromelains

Generic Name
Bromelains
Brand Names
-
Drug Type
Biotech
Chemical Formula
-
CAS Number
9001-00-7
Unique Ingredient Identifier
U182GP2CF3
Background

Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors . It works by selectively inhibiting the biosynthesis of proinflammatory prostaglandins and also has analgesic properties, as well as anticancerous and pro-apoptotic effects. Bromelain holds potential therapeutic effect as a treatment of conditions including angina pectoris, bronchitis, sinusitis, surgical trauma, and osteoarthritis. It is considered as a safe food supplement.

Indication

可用于各种原因所致的炎症、水肿、血肿、血栓症如支气管炎、支气管哮喘、急性肺炎、产后乳房充血、乳腺炎、产后血栓性静脉炎、视网膜炎等,与抗菌药物合用治疗关节炎、关节周围炎、蜂窝织炎、小腿溃疡等均有效。眼科用于治疗视网膜炎。

Associated Conditions
Swelling
Associated Therapies
Eschar removal

Safety of Nebulized Combination Therapy BromAc® in COVID-19 Respiratory Disease

Phase 1
Conditions
COVID-19 Pneumonia
COVID-19
Ventilator Associated Pneumonia
COVID-19 Acute Respiratory Distress Syndrome
Interventions
First Posted Date
2022-02-28
Last Posted Date
2022-02-28
Lead Sponsor
Mucpharm Pty Ltd
Target Recruit Count
30
Registration Number
NCT05258682

Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse

Phase 2
Completed
Conditions
Dental Caries
Dental Plaque
Interventions
Drug: Bromelain
Other: Powdered sugar
First Posted Date
2020-08-13
Last Posted Date
2020-12-03
Lead Sponsor
Indiana University
Target Recruit Count
46
Registration Number
NCT04512482
Locations
🇺🇸

Indiana University School of Dentistry, Indianapolis, Indiana, United States

BromAc for Recurrent Peritoneal Mucinous Tumour or Pseudomyxoma Peritonei

Phase 2
Conditions
Mucinous Adenocarcinoma
Pseudomyxoma Peritonei
Peritoneal Cancer
Mucinous Tumor
Interventions
Drug: Bromelain
Drug: Acetylcysteine
Procedure: Interventional radiology insertion of drain
First Posted Date
2019-06-06
Last Posted Date
2022-03-15
Lead Sponsor
Mucpharm Pty Ltd
Target Recruit Count
62
Registration Number
NCT03976973
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