Aldafermin
- Generic Name
- Aldafermin
- Drug Type
- Biotech
- CAS Number
- 1616639-03-2
- Unique Ingredient Identifier
- IK9NYN31ZM
- Background
Aldafermin is under investigation in clinical trial NCT03912532 (Evaluation of Efficacy, Safety and Tolerability of Aldafermin in a Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study in Subjects With Nonalcoholic Steatohepatitis and Stage 2/3 Fibrosis (ALPINE 2/3)).
A Multi-center Evaluation of Aldafermin in a Randomized, Double-blind, Placebo-controlled Study in Subjects With Primary Sclerosing Cholangitis.
- First Posted Date
- 2024-10-23
- Last Posted Date
- 2025-05-07
- Lead Sponsor
- NGM Biopharmaceuticals, Inc
- Target Recruit Count
- 300
- Registration Number
- NCT06654726
- Locations
- 🇺🇸
NGM Clinical Study Site, Seattle, Washington, United States
Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)
Phase 2
Completed
- Conditions
- Chronic DiarrheaBile Acid DiarrheaIrritable Bowel Syndrome With DiarrheaBile Acid MalabsorptionFunctional DiarrheaBile Acid Malabsorption Syndrome Type II
- Interventions
- Drug: Placebo
- First Posted Date
- 2021-11-22
- Last Posted Date
- 2023-10-12
- Lead Sponsor
- Michael Camilleri, MD
- Target Recruit Count
- 30
- Registration Number
- NCT05130047
- Locations
- 🇺🇸
Mayo Clinic, Rochester, Minnesota, United States
Study of Aldafermin (NGM282) in Subjects With Compensated Cirrhosis (ALPINE 4)
Phase 2
Completed
- Conditions
- Compensated CirrhosisNonalcoholic Steatohepatitis
- Interventions
- Other: Placebo
- First Posted Date
- 2019-12-24
- Last Posted Date
- 2025-03-26
- Lead Sponsor
- NGM Biopharmaceuticals, Inc
- Target Recruit Count
- 160
- Registration Number
- NCT04210245
- Locations
- 🇵🇷
NGM Clinical Study Site, San Juan, Puerto Rico
🇺🇸NGM Clinical Study Site 413, Tucson, Arizona, United States
🇺🇸NGM Clinical Study Site 415, Tucson, Arizona, United States
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