Suramin

Generic Name: Suramin

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₅₁H_₄₀N_₆O_₂₃S_₆

CAS Number: 145-63-1

Unique Ingredient Identifier: 6032D45BEM

Background: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin®.

Indication: For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Anti-trypanosomatid Drug Discovery: Progress and Challenges

Research highlights challenges in anti-trypanosomatid drug discovery, emphasizing the need for new treatments against diseases like Chagas, leishmaniasis, and African trypanosomiasis. Studies explore drug efficacy, resistance mechanisms, and innovative treatment strategies, including proteasome inhibitors and vaccine development, to combat these neglected tropical diseases.

Drug Development Updates

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