Bickel established the International Quit & Recovery Registry at Virginia Tech, aiding scientific understanding of long-term recovery. The registry now includes over 10,000 participants from 60 countries. Bickel also developed the Experimental Tobacco Marketplace to study health behaviors influenced by policy. His legacy includes BEAM Diagnostics, a digital screening tool for behavioral health conditions. Bickel's career was marked by collaboration, mentorship, and numerous awards. Despite a terminal cancer diagnosis, he continued his research, co-authoring studies on addiction until his final months.