Osoresnontrine
- Generic Name
- Osoresnontrine
- Drug Type
- Small Molecule
- Chemical Formula
- C16H17N5O2
- CAS Number
- 1189767-28-9
- Unique Ingredient Identifier
- O9OC34WOAY
- Background
Osoresnontrine is under investigation in clinical trial NCT02281773 (A Study to Investigate the Efficacy, Safety and Tolerability of Four Different Doses of BI 409306 Compared to Placebo Given for 12 Weeks in Patients With Schizophrenia on Stable Antipsychotic Treatment.).
Boehringer Ingelheim's Iclepertin Fails to Meet Endpoints in Phase III Schizophrenia Trials
• Boehringer Ingelheim's iclepertin, a GlyT1 inhibitor, failed to demonstrate statistically significant benefits in improving cognitive function in schizophrenia patients.
• The Phase III CONNEX program, involving over 1,800 patients across 41 countries, did not meet primary or key secondary endpoints at six months.
• As a result of the disappointing outcomes, Boehringer Ingelheim has discontinued the CONNEX-X long-term extension trial.
• The company remains committed to developing solutions for serious mental illnesses, with over 20 investigative therapies in its pipeline.
Drug Development Updates
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