Neostigmine

Generic Name
Neostigmine
Brand Names
Bloxiverz, Prevduo, Prostigmin
Drug Type
Small Molecule
Chemical Formula
C12H19N2O2
CAS Number
59-99-4
Unique Ingredient Identifier
3982TWQ96G
Background

A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike physostigmine, does not cross the blood-brain barrier.

Indication

Neostigmine is used for the symptomatic treatment of myasthenia gravis by improving muscle tone.

Associated Conditions
Curarization therapy, Myasthenia Gravis, Neuromuscular Blockade, Postoperative Urinary Retention (POUR), Acute Colonic Pseudo-Obstruction, Post-operative intestinal atony
Associated Therapies
-
Clinical Trials
Related News

The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications

First Posted Date
2016-08-10
Last Posted Date
2020-03-31
Lead Sponsor
Oregon Health and Science University
Target Recruit Count
200
Registration Number
NCT02861131
Locations
🇺🇸

Oregon Health and Science University, Portland, Oregon, United States

Study to Determine if Administration of Sugammadex Impacts Hospital Efficiency

First Posted Date
2016-08-09
Last Posted Date
2019-04-12
Lead Sponsor
University of South Florida
Target Recruit Count
50
Registration Number
NCT02860507

Effect of Neuromuscular Blockade and Reversal on Breathing

First Posted Date
2016-07-27
Last Posted Date
2020-02-19
Lead Sponsor
Leiden University Medical Center
Target Recruit Count
46
Registration Number
NCT02845375
Locations
🇳🇱

Leiden University Medical Center, Leiden, ZH, Netherlands

The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

First Posted Date
2016-07-21
Last Posted Date
2019-10-29
Lead Sponsor
Iuliu Hatieganu University of Medicine and Pharmacy
Target Recruit Count
120
Registration Number
NCT02839668
Locations
🇷🇴

IOCN Prof Dr I chiricuta, Cluj-Napoca, Romania

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

First Posted Date
2016-03-04
Last Posted Date
2016-10-25
Lead Sponsor
University of Florence
Target Recruit Count
58
Registration Number
NCT02698969
Locations
🇮🇹

Azienda Ospdaliero Universitaria Careggi, Florence, Italy

Sugammadex/Neostigmine and Liver Transplantation

First Posted Date
2016-03-03
Last Posted Date
2021-09-21
Lead Sponsor
Azienda Ospedaliera S. Maria della Misericordia
Target Recruit Count
40
Registration Number
NCT02697929
Locations
🇮🇹

AOU Santa Maria della Misericordia, Udine, Italy

Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery

First Posted Date
2016-01-28
Last Posted Date
2018-06-28
Lead Sponsor
KK Women's and Children's Hospital
Target Recruit Count
184
Registration Number
NCT02666014
Locations
🇸🇬

KK Women's and Children's Hospital, Singapore, Singapore

Use of High Resolution Colonic Manometry in Studying Motility

First Posted Date
2015-10-14
Last Posted Date
2021-09-28
Lead Sponsor
James J. Peters Veterans Affairs Medical Center
Registration Number
NCT02574611
Locations
🇺🇸

James J. Peters VA Medical Center, Bronx, New York, United States

Quality of Awakening and Impact on Cognitive Function After Administration of Sugammadex in Robotic Radical Cystectomy

Not Applicable
Completed
Conditions
Anesthesiology Management
Interventions
Drug: sugammadex
Drug: Neostigmine
First Posted Date
2015-05-27
Last Posted Date
2018-08-31
Lead Sponsor
Regina Elena Cancer Institute
Target Recruit Count
120
Registration Number
NCT02454504
Locations
🇮🇹

Regina Elena Cancer Institute, Rome, RM, Italy

Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection

First Posted Date
2015-04-13
Last Posted Date
2016-02-02
Lead Sponsor
Cairo University
Target Recruit Count
60
Registration Number
NCT02414880
Locations
🇪🇬

National Liver institute, Garden City, Cairo, Egypt

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