Dactinomycin
- Generic Name
- Dactinomycin
- Brand Names
- Cosmegen
- Drug Type
- Small Molecule
- Chemical Formula
- C62H86N12O16
- CAS Number
- 50-76-0
- Unique Ingredient Identifier
- 1CC1JFE158
- Background
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (Fro...
- Indication
For the treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen
- Associated Conditions
- Ewing's Sarcoma, Gestational Trophoblastic Neoplasia, Osteosarcoma, Ovarian Cancer, Rhabdomyosarcomas, Wilms' tumor, Metastatic nonseminomatous Testicular cancer
- Associated Therapies
- -
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