Modafinil

Generic Name
Modafinil
Brand Names
Provigil
Drug Type
Small Molecule
Chemical Formula
C15H15NO2S
CAS Number
68693-11-8
Unique Ingredient Identifier
R3UK8X3U3D
Background

Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactiva...

Indication

To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.

Associated Conditions
Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance
Associated Therapies
-
Clinical Trials
Related News

Neuromodulation and Language Acquisition (Project Stage Ia)

Phase 4
Terminated
Conditions
Healthy
First Posted Date
2005-01-27
Last Posted Date
2010-01-27
Lead Sponsor
University Hospital Muenster
Target Recruit Count
100
Registration Number
NCT00102284
Locations
🇩🇪

Dept. of Neurology, University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany

Modafinil for the Treatment of Cocaine Dependence - 1

Phase 2
Completed
Conditions
Cocaine-Related Disorders
First Posted Date
2004-12-23
Last Posted Date
2017-01-12
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Target Recruit Count
210
Registration Number
NCT00100100
Locations
🇺🇸

Cincinnati Addiction Research Center, Cincinnati, Ohio, United States

🇺🇸

New York VA Medical Center, New York, New York, United States

🇺🇸

Boston University Medical Center, Boston, Massachusetts, United States

and more 3 locations

Modafinil to Treat Fatigue in Post-Polio Syndrome

Phase 3
Terminated
Conditions
Postpoliomyelitis Syndrome
First Posted Date
2003-08-21
Last Posted Date
2008-08-27
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Target Recruit Count
30
Registration Number
NCT00067496
Locations
🇺🇸

National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, United States

Effects of Modafinil on Brain Function in Patients With Schizophrenia

Phase 1
Completed
Conditions
Schizoaffective Disorder
Schizophrenia
First Posted Date
2003-04-07
Last Posted Date
2019-12-09
Lead Sponsor
National Institute of Mental Health (NIMH)
Target Recruit Count
176
Registration Number
NCT00057707
Locations
🇺🇸

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Modafinil in Treating Fatigue and Behavioral Change in Patients With Primary Brain Cancer

First Posted Date
2003-01-27
Last Posted Date
2020-08-03
Lead Sponsor
Jonsson Comprehensive Cancer Center
Target Recruit Count
29
Registration Number
NCT00052286
Locations
🇺🇸

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, United States

Modafinil in Treating Fatigue in Patients Receiving Chemotherapy for Cancer

First Posted Date
2003-01-27
Last Posted Date
2015-10-15
Lead Sponsor
Gary Morrow
Target Recruit Count
837
Registration Number
NCT00042848
Locations
🇺🇸

St. Mary-Corwin Regional Medical Center, Pueblo, Colorado, United States

🇺🇸

CCOP - Evanston, Evanston, Illinois, United States

🇺🇸

CCOP - North Shore University Hospital, Manhasset, New York, United States

and more 32 locations

Evaluation of Modafinil as a Cocaine Treatment Medication and Interactions With Cocaine - 1

First Posted Date
2002-04-08
Last Posted Date
2017-01-11
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Target Recruit Count
12
Registration Number
NCT00033046
Locations
🇺🇸

Medical University of South Carolina, Charleston, South Carolina, United States

© Copyright 2024. All Rights Reserved by MedPath
HomeTerms & ConditionsPrivacy Policy