Modafinil
- Generic Name
- Modafinil
- Brand Names
- Provigil
- Drug Type
- Small Molecule
- Chemical Formula
- C15H15NO2S
- CAS Number
- 68693-11-8
- Unique Ingredient Identifier
- R3UK8X3U3D
- Background
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactiva...
- Indication
To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy.
- Associated Conditions
- Attention Deficit Hyperactivity Disorder (ADHD), Fatigue, Major Depressive Disorder (MDD), Narcolepsy, Obstructive Sleep Apnea (OSA), Shift-work related sleep disturbance
- Associated Therapies
- -
Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study
- Conditions
- Interventions
- First Posted Date
- 2013-09-26
- Last Posted Date
- 2016-01-21
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Target Recruit Count
- 24
- Registration Number
- NCT01951508
- Locations
- 🇨🇭
University Hospital Basel, Basel, Basel-Stadt, Switzerland
Antipsychotic Effects on Brain Function in Schizophrenia
- Conditions
- Interventions
- First Posted Date
- 2013-08-01
- Last Posted Date
- 2020-04-20
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 4
- Registration Number
- NCT01913327
- Locations
- 🇺🇸
University of California, San Francisco, California, United States
Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2013-07-19
- Last Posted Date
- 2014-04-03
- Lead Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
- Target Recruit Count
- 40
- Registration Number
- NCT01903824
- Locations
- 🇳🇱
Teva Investigational Site 38051, Leiden, Netherlands
Treatment of Post Stroke Fatigue With a Wakefulness Promoting Agent
- First Posted Date
- 2013-02-27
- Last Posted Date
- 2015-06-24
- Lead Sponsor
- Herlev Hospital
- Target Recruit Count
- 41
- Registration Number
- NCT01800097
- Locations
- 🇩🇰
Department of Neurology, Herlev Hospital,, Herlev, Denmark
Palliative Morphine With or Without Concurrent Modafinil
- First Posted Date
- 2013-01-11
- Last Posted Date
- 2013-01-11
- Lead Sponsor
- Dr. Rajendra Prasad Government Medical College
- Target Recruit Count
- 200
- Registration Number
- NCT01766323
- Locations
- 🇮🇳
Tanda Government Medical College and Hospital, Kangra, Himachal Pradesh, India
Modafinil in the Treatment of PTSD (Posttraumatic Stress Disorder)
- First Posted Date
- 2012-11-14
- Last Posted Date
- 2012-11-14
- Lead Sponsor
- Biomedical Research Foundation
- Target Recruit Count
- 40
- Registration Number
- NCT01726088
- Locations
- 🇺🇸
CAVHS Eugene Towbin VA Medical Center, North Little Rock, Arkansas, United States
Pharmacological Cognitive Enhancement
- Conditions
- Interventions
- First Posted Date
- 2012-09-12
- Last Posted Date
- 2012-09-13
- Target Recruit Count
- 26
- Registration Number
- NCT01684306
- Locations
- 🇮🇹
Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti, Italy
Modafinil - Escitalopram Study for Cocaine Dependence
- Conditions
- Interventions
- First Posted Date
- 2012-05-18
- Last Posted Date
- 2012-05-18
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 68
- Registration Number
- NCT01601730
- Locations
- 🇺🇸
Michael E. DeBakey VA Medical Center, Houston, Texas, United States
Effects of Donepezil and Memantine on Cognitive Functions After a Sleep Deprivation Challenge in Healthy Volunteers
- First Posted Date
- 2011-10-27
- Last Posted Date
- 2015-02-04
- Lead Sponsor
- Qualissima
- Target Recruit Count
- 36
- Registration Number
- NCT01461174
- Locations
- 🇫🇷
CIC, Lille, France
🇫🇷MEDES, Toulouse, France
Modafinil in Cancer Related Fatigue
- Conditions
- Interventions
- First Posted Date
- 2011-09-26
- Last Posted Date
- 2012-03-23
- Lead Sponsor
- Indira Gandhi Medical College, Shimla
- Target Recruit Count
- 217
- Registration Number
- NCT01440621
- Locations
- 🇮🇳
Regional Cancer Centre, Shimla, Himachal Pradesh, India
Drug Development Updates
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