Collagenase clostridium histolyticum
- Generic Name
- Collagenase clostridium histolyticum
- Brand Names
- Qwo, Santyl, Xiaflex
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 9001-12-1
- Unique Ingredient Identifier
- 9X7O8V25IT
- Background
Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ulcers.
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- Indication
Collagenase clostridium histolyticum is indicated for the treatment of adults with Dupuytren's contracture with a palpable cord. Additionally, it is used to treat men with Peyronie's disease diagnosed with a penile curvature deformity of at least a 30-degree angle at the beginning of therapy in addition to palpable plaques. Collagenase ointment is used for t...
- Associated Conditions
- Dupuytren's Contracture of the Hand (Viking's Disease), Peyronie's Disease, Necrotic tissue
- Associated Therapies
- -
Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease
- Conditions
- First Posted Date
- 1999-10-19
- Last Posted Date
- 2015-03-25
- Lead Sponsor
- State University of New York
- Target Recruit Count
- 36
- Registration Number
- NCT00004409
- Locations
- 🇺🇸
Stanford University Hospital, Palo Alto, California, United States
🇺🇸State University of New York Health Sciences Center - Stony Brook, Stony Brook, New York, United States
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