• Phase III trial results for semaglutide (EVOKE and EVOKE Plus) are anticipated in September 2025, investigating its potential to slow cognitive decline in Alzheimer's patients.
• Studies suggest GLP-1 drugs like semaglutide and liraglutide may reduce Alzheimer's risk and slow cognitive decline, possibly by improving insulin resistance in the brain.
• Experts emphasize the need for large, controlled trials to confirm GLP-1s' efficacy and safety for chronic use in preventing or treating Alzheimer's disease.
• Researchers are exploring GLP-1/GIP receptor agonists like Kariya's KP405, designed to better penetrate the brain, potentially minimizing side effects associated with GLP-1 treatments.