MedPath

ION-717

Generic Name
ION-717

GLP-1 Receptor Agonists Show Promise in Alzheimer's Disease: Key Clinical Trial Readouts Expected in 2025

• Phase III trial results for semaglutide (EVOKE and EVOKE Plus) are anticipated in September 2025, investigating its potential to slow cognitive decline in Alzheimer's patients. • Studies suggest GLP-1 drugs like semaglutide and liraglutide may reduce Alzheimer's risk and slow cognitive decline, possibly by improving insulin resistance in the brain. • Experts emphasize the need for large, controlled trials to confirm GLP-1s' efficacy and safety for chronic use in preventing or treating Alzheimer's disease. • Researchers are exploring GLP-1/GIP receptor agonists like Kariya's KP405, designed to better penetrate the brain, potentially minimizing side effects associated with GLP-1 treatments.
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