Hyaluronic acid

Generic Name
Hyaluronic acid
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C28H44N2O23
CAS Number
9004-61-9
Unique Ingredient Identifier
S270N0TRQY
Background

Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan found in connective, epithelial, and neural tissues; it was first isolated in 1934. Karl Meyer and John Palmer obtained glycosaminoglycan (GAG) from the bovine eye, giving it the name “hyaluronic acid”. HA is involved in many important physiological processes, including but not limited to woun...

Indication

The intra-articular preparations of hyaluronic acid are indicated for knee pain associated with osteoarthritis. Hyaluronic acid is used in cosmetic applications to prevent and reduce the appearance of wrinkles on the face, and as a dermal filler to correct facial imperfections or other imperfections on other parts of the body. It is frequently an ingredient ...

Associated Conditions
Actinic Keratosis (AK), Burns, Chronic Skin Ulcers, Conjunctivitis, Dehydration, Dermabrasion, Dermatosis, Dry Eyes, Facial Defect, Interstitial Cystitis, Keratoconjunctivitis, Ocular Irritation, Osteoarthritis (OA), Pain of the knee, Seasonal Allergic Conjunctivitis, Skin Burn, Skin Irritation, Skin fissures, Tissue Adhesions, Varicose Ulcers, Wound, Eye discomfort, Facial fine wrinkling, Sensation of burning in the eyes, Superficial Wounds
Associated Therapies
Dermal Filler, Promotion of wound healing, Synovial Fluid Lubrication
nature.com
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Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy

Studies highlight endothelial dysfunction in critical illness, sepsis, and trauma, with biomarkers indicating glycocalyx injury and potential therapeutic targets like angiopoietin-Tie2 pathways.
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