Chlorhexidine

Generic Name: Chlorhexidine

Brand Names: Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur

Drug Type: Small Molecule

Chemical Formula: C_₂₂H_₃₀Cl_₂N_₁₀

CAS Number: 55-56-1

Unique Ingredient Identifier: R4KO0DY52L

Background: Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...

Indication: Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...

Associated Conditions: Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation

Associated Therapies: Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection

Clinical Trials

A Pilot Study to Evaluate Skin Swabbing with Chlorhexidine to Prevent Skin and Soft Tissue Infections Among People Who Inject Drugs

Phase 4

Completed

Conditions: Opioid Use Disorder
Infection Control and Prevention
Injection Drug Use

Interventions: Drug: Chlorhexidine gluconate
Drug: Isopropyl Alcohol 70% Topical Application Solution
Behavioral: Skin Prep Before Injecting Recreational/Street Drugs

First Posted Date: 2024-12-13

Last Posted Date: 2024-12-13

Lead Sponsor: Gabriel John Culbert

Target Recruit Count: 56

Registration Number: NCT06733506

Locations: 🇺🇸
University of Illinois Chicago, Chicago, Illinois, United States

Effect of Chlorhexidine Gluconate in Oral Care of Patients With Endotracheal Intubation Based on 16sRNA Technology

Not Applicable

Completed

Conditions: Intubation, Endotracheal
Oral Hygiene

Interventions: Other: normal saline
Drug: Chlorhexidine Gluconate

First Posted Date: 2024-11-15

Last Posted Date: 2024-11-15

Lead Sponsor: Shanghai 10th People's Hospital

Target Recruit Count: 76

Registration Number: NCT06691841

Locations: 🇨🇳
Changcui Qiu, Shanghai, China

Chlorhexidine Lavage for Recurrent Urinary Tract Infection

Phase 4

Not yet recruiting

Conditions: Urinary Tract Infections
Recurrent Urinary Tract Infection

Interventions: Drug: Chlorhexidine
Drug: Sterile Water

First Posted Date: 2024-09-19

Last Posted Date: 2024-09-19

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 136

Registration Number: NCT06598514

Locations: 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States

The Effect of Different Types of Mouthwash on Extraction Sockets' Healing

Phase 4

Not yet recruiting

Conditions: Extraction Socket Healing
Quality of Life
Postoperative Complications

Interventions: Drug: Bone Bioactive Liquid
Drug: Chlorhexidine Gluconate
Drug: Warm Saline Mouth Rinse
Drug: Hyaluronic Acid mouthwash

First Posted Date: 2024-09-09

Last Posted Date: 2024-09-09

Lead Sponsor: University of Jordan

Target Recruit Count: 100

Registration Number: NCT06587880

Locations: 🇯🇴
University of Jordan hospital, Amman, Jordan

Comparison of the Effects of Oral Ulceration Healing in Patients Wearing a Removable Denture

Not Applicable

Completed

Conditions: Oral Mucosa; Ulcer

Interventions: Drug: Chlorhexidine Gluconate
Drug: Choline Salicylate 8.7 % Oral Gel
Other: control group

First Posted Date: 2024-08-01

Last Posted Date: 2024-08-01

Lead Sponsor: Medical University of Silesia

Target Recruit Count: 27

Registration Number: NCT06531720

Locations: 🇵🇱
Department of TMD Silesian Medical University, Zabrze, Poland

Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement

Phase 3

Recruiting

Conditions: Penile Prosthesis; Complications, Infection or Inflammation
Erectile Dysfunction

Interventions: Drug: Chlorhexidine
Drug: Gentamicin
Drug: Rifampin

First Posted Date: 2024-07-05

Last Posted Date: 2024-08-26

Lead Sponsor: Rush University Medical Center

Target Recruit Count: 100

Registration Number: NCT06489431

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States
🇺🇸
Uropartners Surgery Center, Des Plaines, Illinois, United States