Chlorhexidine
- Generic Name
- Chlorhexidine
- Brand Names
- Betasept, Hibiclens, Instillagel, Nupro Chlorhexidine, Oris, Oro-Clense, Paroex, Perichlor, Peridex, Periochip, Periogard, Prevora, X-pur
- Drug Type
- Small Molecule
- Chemical Formula
- C22H30Cl2N10
- CAS Number
- 55-56-1
- Unique Ingredient Identifier
- R4KO0DY52L
- Background
Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms. It is one of the most common skin and mucous membrane antiseptic agents in use today. The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings a...
- Indication
Chlorhexidine is available over-the-counter in various formulations (e.g. solution, sponge, cloth, swab) as a topical antiseptic to sanitize prior to surgeries and/or medical procedures. Dental formulations, available by prescription only, include an oral rinse indicated for the treatment of gingivitis and a slow-release "chip" which is inserted into periodo...
- Associated Conditions
- Aphthous ulcer, Catarrh of the throat, Chemotherapy Induced Oral Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival Diseases, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Sore Throat, Stomatitis, Surgical Wounds, Tissue Damage, Tonsillitis, Ulcers, Leg, Wound Infections, Bacterial skin infections, Dry, cracked skin, Gum pain, Moderate Gingivitis, Oral infections, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation
- Associated Therapies
- Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Promotion of wound healing, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Oral antisepsis, Oral disinfection
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
- First Posted Date
- 2008-02-07
- Last Posted Date
- 2008-02-07
- Lead Sponsor
- King Edward Memorial Hospital
- Target Recruit Count
- 512
- Registration Number
- NCT00610324
- Locations
- 🇮🇳
Medical-Neuro Intensive Care Unit, K E M Hospital, Parel, Mumbai, Maharashtra, India
Clinical Performance of a Chlorhexidine Antimicrobial Dressing
- Conditions
- Interventions
- First Posted Date
- 2007-08-16
- Last Posted Date
- 2024-10-24
- Lead Sponsor
- Solventum US LLC
- Target Recruit Count
- 68
- Registration Number
- NCT00516906
Chlorhexidine Versus Povidone-Iodine for Prevention of Epidural Needle Contamination in the Parturient
- Conditions
- Interventions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2009-02-16
- Lead Sponsor
- University of Saskatchewan
- Target Recruit Count
- 400
- Registration Number
- NCT00223002
- Locations
- 🇨🇦
Royal University Hospital, Saskatoon, Saskatchewan, Canada
Effect of Chlorhexidine Skin Cleansing on Skin Flora
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2018-04-20
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 210
- Registration Number
- NCT00198679
- Locations
- 🇧🇩
Dhaka Shishu Hospital, Dhaka, Bangladesh
Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn
- First Posted Date
- 2005-08-29
- Last Posted Date
- 2007-09-24
- Lead Sponsor
- Centers for Disease Control and Prevention
- Target Recruit Count
- 8000
- Registration Number
- NCT00136370
- Locations
- 🇿🇦
Chris Hani Baragwanath Hospital, Soweto, Gauteng, South Africa
Prevention Management Model for Early Childhood Caries (MAYA Project)
- Conditions
- Interventions
- First Posted Date
- 2003-08-08
- Last Posted Date
- 2022-03-21
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 361
- Registration Number
- NCT00066950
- Locations
- 🇺🇸
San Ysidro Health Center, San Ysidro, California, United States
The Safety and Effectiveness of Peridex in Preventing or Delaying Fungal Infections of the Mouth in HIV-Infected Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Procter and Gamble
- Registration Number
- NCT00002431
- Locations
- 🇺🇸
Bering Dental Clinic, Houston, Texas, United States
🇺🇸Hermann Hosp / Univ Texas Health Science Ctr, Houston, Texas, United States
🇺🇸UCSF / Stomatology Clinical Ctr, San Francisco, California, United States
A Study of Chlorhexidine in the Prevention of HIV-1 Transmission From Mothers to Their Babies
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2008-09-30
- Target Recruit Count
- 150
- Registration Number
- NCT00006075
- Locations
- 🇺🇸
Ann Koonce, Research Triangle Park, North Carolina, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.