Amiodarone
- Generic Name
- Amiodarone
- Brand Names
- Nexterone, Pacerone
- Drug Type
- Small Molecule
- Chemical Formula
- C25H29I2NO3
- CAS Number
- 1951-25-3
- Unique Ingredient Identifier
- N3RQ532IUT
- Background
Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxicity and possibly death, amiodarone use s...
- Indication
The FDA approved indications for amiodarone are recurrent ventricular fibrillation (VF) and recurrent hemodynamically unstable ventricular tachycardia (VT). The FDA emphasizes that this drug should only be given in these conditions when they are clinically documented and have not responded to normal therapeutic doses of other antiarrhythmic agents, or when o...
- Associated Conditions
- Atrial Fibrillation, Supraventricular Tachycardia (SVT), Recurrent Ventricular fibrillation, Recurrent hemodynamically unstable Ventricular tachycardia
- Associated Therapies
- -
Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation or Atrial Flutter
- Conditions
- Interventions
- First Posted Date
- 2010-10-27
- Last Posted Date
- 2023-08-07
- Lead Sponsor
- Portola Pharmaceuticals
- Target Recruit Count
- 189
- Registration Number
- NCT01229254
n-3 Polyunsaturated Fatty Acids (PUFAs) in the Prevention of Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2010-09-10
- Last Posted Date
- 2012-01-20
- Target Recruit Count
- 199
- Registration Number
- NCT01198275
- Locations
- 🇮🇹
Arrhytmias and Heart failure Unit-Spedali Civili Hospital, Brescia, Italy
Effect of Amiodarone on the Procedure Outcome in Long-standing Persistent Atrial Fibrillation Undergoing Pulmonary Vein Antral Isolation
- First Posted Date
- 2010-08-02
- Last Posted Date
- 2014-08-21
- Lead Sponsor
- Texas Cardiac Arrhythmia Research Foundation
- Target Recruit Count
- 176
- Registration Number
- NCT01173809
- Locations
- 🇺🇸
St.David's Medical Center, Austin, Texas, United States
Catheter Ablation Versus Amiodarone for Shock Prophylaxis in Defibrillator Patients With Ventricular Tachycardia
- Conditions
- Interventions
- First Posted Date
- 2010-04-01
- Last Posted Date
- 2020-01-29
- Lead Sponsor
- Population Health Research Institute
- Target Recruit Count
- 12
- Registration Number
- NCT01097330
- Locations
- 🇺🇸
Texas Cardiac Arrhythmia Research Foundation, Austin, Texas, United States
🇨🇦Southlake Regional Health Centre, Newmarket, Ontario, Canada
🇨🇦Hamilton Health Sciences, Hamilton, Ontario, Canada
Dose Ranging Study of Celivarone With Amiodarone as Calibrator for the Prevention of Implantable Cardioverter Defibrillator (ICD) Interventions or Death
- Conditions
- Interventions
- First Posted Date
- 2009-10-12
- Last Posted Date
- 2016-05-30
- Lead Sponsor
- Sanofi
- Target Recruit Count
- 486
- Registration Number
- NCT00993382
- Locations
- 🇺🇸
Investigational Site Number 840045, Chicago, Illinois, United States
🇩🇪Investigational Site Number 276005, Bad Neustadt, Germany
🇦🇺Investigational Site Number 036003, Woolloongabba, Australia
Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2009-08-06
- Last Posted Date
- 2018-04-26
- Lead Sponsor
- MaineHealth
- Target Recruit Count
- 304
- Registration Number
- NCT00953212
- Locations
- 🇺🇸
Maine Medical Center, Portland, Maine, United States
In-hospital Cardiac Arrest - Dynamics and State Transitions
- Conditions
- First Posted Date
- 2009-06-15
- Last Posted Date
- 2018-09-05
- Lead Sponsor
- St. Olavs Hospital
- Target Recruit Count
- 285
- Registration Number
- NCT00920244
- Locations
- 🇳🇴
St.Olavs Hospital, Department of Anesthesia, Trondheim, Norway
The Effect of Short Term Amiodarone Treatment After Catheter Ablation for Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2009-01-22
- Last Posted Date
- 2014-03-05
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 212
- Registration Number
- NCT00826826
- Locations
- 🇩🇰
Rigshospitalet, Copenhagen, Denmark
🇩🇰Gentofte University Hospital, Hellerup, Denmark
A Randomized, Placebo-Controlled, Double-Blind, Double Dummy Trial To Determine The Relative Effect Of Pm101 Versus Placebo And Amiodarone IV On Blood Pressure In Subjects With Stable Congestive Heart Failure
- First Posted Date
- 2008-08-21
- Last Posted Date
- 2017-09-11
- Lead Sponsor
- Prism Pharmaceuticals
- Registration Number
- NCT00739193
Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD
- Conditions
- Interventions
- First Posted Date
- 2008-08-08
- Last Posted Date
- 2019-04-10
- Lead Sponsor
- Texas Cardiac Arrhythmia Research Foundation
- Target Recruit Count
- 203
- Registration Number
- NCT00729911
- Locations
- 🇺🇸
Texas Cardiac Arrhythmia Research Foundation, Austin, Texas, United States
Drug Development Updates
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