Cimetidine
- Generic Name
- Cimetidine
- Brand Names
- Good Sense Heartburn Relief, Tagamet
- Drug Type
- Small Molecule
- Chemical Formula
- C10H16N6S
- CAS Number
- 51481-61-9
- Unique Ingredient Identifier
- 80061L1WGD
- Background
A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant therapy.
- Indication
Cimetidine is indicated to reduce gastric acid secretion and to treat the following disease states: duodenal ulcers, non-malignant gastric ulcers, gastroesophageal reflux disease, and pathological hypersecretion associated with Zollinger-Ellison Syndrome, systemic mastocytosis, and multiple endocrine adenomas. It is indicated for prophylaxis of recurrent gas...
- Associated Conditions
- Cystic Fibrosis (CF), Gastric hypersecretion, Gastro-esophageal Reflux Disease (GERD), Gastrointestinal Symptoms, Heartburn, Active Duodenal ulcer, Benign gastric ulcers, Develop NSAID-induced gastric ulcers, Recurrent Ulcers, Duodenal and Gastric
- Associated Therapies
- -
High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
- Conditions
- Interventions
- First Posted Date
- 2012-12-28
- Last Posted Date
- 2016-03-08
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 239
- Registration Number
- NCT01757275
- Locations
- 🇨🇳
Research Site, Xian, China
Evaluating The Effects Of Cimetidine On The Elimination Of PD 0332334 From The Body
- Conditions
- Interventions
- First Posted Date
- 2008-12-02
- Last Posted Date
- 2010-02-17
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 12
- Registration Number
- NCT00800280
- Locations
- 🇺🇸
Pfizer Investigational Site, New Haven, Connecticut, United States
Papillary Serous Carcinoma of the Endometrium
- Conditions
- Interventions
- First Posted Date
- 2007-08-13
- Last Posted Date
- 2014-07-03
- Lead Sponsor
- M.D. Anderson Cancer Center
- Target Recruit Count
- 30
- Registration Number
- NCT00515073
- Locations
- 🇺🇸
M. D. Anderson Cancer Center - Orlando, Orlando, Florida, United States
🇺🇸UT MD Anderson Cancer Center, Houston, Texas, United States
Biological Therapy in Treating Patients With Metastatic Cancer
- Conditions
- First Posted Date
- 2004-07-01
- Last Posted Date
- 2011-05-11
- Lead Sponsor
- Hoag Memorial Hospital Presbyterian
- Target Recruit Count
- 30
- Registration Number
- NCT00002733
- Locations
- 🇺🇸
Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States
A Study to Evaluate the Effect of Cimetidine on CD4 Lymphocyte Counts in HIV Infection
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Community Research Initiative of New England
- Registration Number
- NCT00002092
- Locations
- 🇺🇸
CRI of New England, Brookline, Massachusetts, United States
Drug Development Updates
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