戊柔比星 (Valstar)

概览

Valrubicin is an anthracycline used intravesically in the treatment of BCG-resistant bladder carcinoma.

作用机制

Valrubicin is an anthracycline that affects a variety of inter-related biological functions, most of which involve nucleic acid metabolism. It readily penetrates into cells, where after DNA intercalation, it inhibits the incorporation of nucleosides into nucleic acids, causes extensive chromosomal damage, and arrests cell cycle in G2. Although valrubicin does not bind strongly to DNA, a principal mechanism of its action, mediated by valrubicin metabolites, is interference with the normal DNA breaking-resealing action of DNA topoisomerase II.

适应症

For the treatment of cancer of the bladder.

• In situ BCG-refractory Bladder carcinoma