Afatinib

Generic Name
Afatinib
Brand Names
Gilotrif, Giotrif
Drug Type
Small Molecule
Chemical Formula
C24H25ClFN5O3
CAS Number
850140-72-6
Unique Ingredient Identifier
41UD74L59M
Background

Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif . For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations as detected by ...

Indication

Afatinib is a kinase inhibitor indicated as monotherapy for the first-line treatment of (a) Epidermal Growth Factor Receptor (EGFR) TKI (tyrosine kinase inhibitor)-naive adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose tumours have non-resistant EGFR mutations as detected by an FDA-approved test , and (b) adult pa...

Associated Conditions
Metastatic Non-Small Cell Lung Cancer, Refractory, metastatic squamous cell Non-small cell lung cancer
Associated Therapies
-

A Phase I Dose Escalation Trial of Afatinib Plus Gemcitabine or Plus Docetaxel

First Posted Date
2010-12-02
Last Posted Date
2016-05-30
Lead Sponsor
Boehringer Ingelheim
Target Recruit Count
94
Registration Number
NCT01251653
Locations
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1200.93.33002 Boehringer Ingelheim Investigational Site, Dijon, France

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1200.93.33001 Boehringer Ingelheim Investigational Site, Saint-Herblain cedex, France

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1200.93.33003 Boehringer Ingelheim Investigational Site, Toulouse, France

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